XB-ART-47455
Prog Mol Biol Transl Sci
2013 Jan 01;116:387-407. doi: 10.1016/B978-0-12-394311-8.00017-0.
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Beta-catenin versus the other armadillo catenins: assessing our current view of canonical Wnt signaling.
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The prevailing view of canonical Wnt signaling emphasizes the role of beta-catenin acting downstream of Wnt activation to regulate transcriptional activity. However, emerging evidence indicates that other armadillo catenins in vertebrates, such as members of the p120 subfamily, convey parallel signals to the nucleus downstream of canonical Wnt pathway activation. Their study is thus needed to appreciate the networked mechanisms of canonical Wnt pathway transduction, especially as they may assist in generating the diversity of Wnt effects observed in development and disease. In this chapter, we outline evidence of direct canonical Wnt effects on p120 subfamily members in vertebrates and speculate upon these catenins' roles in conjunction with or aside from beta-catenin.
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???displayArticle.grants??? [+]
1K01DK092320 NIDDK NIH HHS , GM052112 NIGMS NIH HHS , K01 DK092320 NIDDK NIH HHS , R01 GM052112 NIGMS NIH HHS , 1K01DK092320 NIDDK NIH HHS, K01 DK092320 NIDDK NIH HHS
Species referenced: Xenopus
Genes referenced: ctnnd1
References [+] :
Abe,
EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt.
2008, Pubmed
Abe, EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt. 2008, Pubmed
Anastasiadis, Inhibition of RhoA by p120 catenin. 2000, Pubmed
Anastasiadis, p120-ctn: A nexus for contextual signaling via Rho GTPases. 2007, Pubmed
Andl, No one-way street: cross-talk between e-cadherin and receptor tyrosine kinase (RTK) signaling: a mechanism to regulate RTK activity. 2005, Pubmed
Bahmanyar, beta-Catenin is a Nek2 substrate involved in centrosome separation. 2008, Pubmed
Bass-Zubek, Plakophilins: multifunctional scaffolds for adhesion and signaling. 2009, Pubmed
Bonné, Defining desmosomal plakophilin-3 interactions. 2003, Pubmed
Bonné, Plakophilin-3, a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells. 1999, Pubmed
Bornslaeger, Plakophilin 1 interferes with plakoglobin binding to desmoplakin, yet together with plakoglobin promotes clustering of desmosomal plaque complexes at cell-cell borders. 2001, Pubmed
Casagolda, A p120-catenin-CK1epsilon complex regulates Wnt signaling. 2010, Pubmed
Chen, Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling. 2002, Pubmed
Chen, p120 catenin associates with kinesin and facilitates the transport of cadherin-catenin complexes to intercellular junctions. 2003, Pubmed
Clevers, Wnt/β-catenin signaling and disease. 2012, Pubmed
Cordenonsi, The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. 2011, Pubmed
Daniel, The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. 1999, Pubmed
Daniel, Dancing in and out of the nucleus: p120(ctn) and the transcription factor Kaiso. 2007, Pubmed
Delva, The desmosome. 2009, Pubmed
Dickinson, A polarized epithelium organized by beta- and alpha-catenin predates cadherin and metazoan origins. 2011, Pubmed
Foubert, Key signalling nodes in mammary gland development and cancer. The Snail1-Twist1 conspiracy in malignant breast cancer progression. 2010, Pubmed
Franke, The junctions that don't fit the scheme: special symmetrical cell-cell junctions of their own kind. 2009, Pubmed
Gandjbakhch, Plakophilin 2A is the dominant isoform in human heart tissue: consequences for the genetic screening of arrhythmogenic right ventricular cardiomyopathy. 2011, Pubmed
Garcia-Gras, Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy. 2006, Pubmed
Garrod, Desmosome structure, composition and function. 2008, Pubmed
Gottardi, Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes. 2004, Pubmed , Xenbase
Gu, Caspase-3 cleavage links delta-catenin to the novel nuclear protein ZIFCAT. 2011, Pubmed , Xenbase
Haegebarth, Wnt signaling, lgr5, and stem cells in the intestine and skin. 2009, Pubmed
Hatzfeld, Plakophilins: Multifunctional proteins or just regulators of desmosomal adhesion? 2007, Pubmed
Haÿ, Peptide-based mediated disruption of N-cadherin-LRP5/6 interaction promotes Wnt signaling and bone formation. 2012, Pubmed
Heuberger, Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling. 2010, Pubmed
Hikasa, Regulation of TCF3 by Wnt-dependent phosphorylation during vertebrate axis specification. 2010, Pubmed , Xenbase
Hong, Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members. 2010, Pubmed , Xenbase
Hong, Down's-syndrome-related kinase Dyrk1A modulates the p120-catenin-Kaiso trajectory of the Wnt signaling pathway. 2012, Pubmed , Xenbase
Hosking, The transcriptional repressor Glis2 is a novel binding partner for p120 catenin. 2007, Pubmed
Huber, Three-dimensional structure of the armadillo repeat region of beta-catenin. 1997, Pubmed
Ichii, p120-catenin regulates microtubule dynamics and cell migration in a cadherin-independent manner. 2007, Pubmed
Jeanes, Cadherins and cancer: how does cadherin dysfunction promote tumor progression? 2008, Pubmed
Katoh, Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis. 2007, Pubmed
Kim, E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components. 2011, Pubmed
Kim, Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin. 2004, Pubmed , Xenbase
Koutras, A nuclear function for the presenilin 1 neuronal partner NPRAP/δ-catenin. 2011, Pubmed
Kwiatkowski, In vitro and in vivo reconstitution of the cadherin-catenin-actin complex from Caenorhabditis elegans. 2010, Pubmed
Lecuit, alpha-catenin mechanosensing for adherens junctions. 2010, Pubmed
Lilien, The regulation of cadherin-mediated adhesion by tyrosine phosphorylation/dephosphorylation of beta-catenin. 2005, Pubmed
Logan, Nuclear beta-catenin is required to specify vegetal cell fates in the sea urchin embryo. 1999, Pubmed
Maeda, Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line. 2004, Pubmed
Maher, Activity of the beta-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion. 2009, Pubmed
McCrea, A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin. 1991, Pubmed , Xenbase
McCrea, The catenin family at a glance. 2010, Pubmed
McCrea, Induction of a secondary body axis in Xenopus by antibodies to beta-catenin. 1993, Pubmed , Xenbase
McCrea, Junctional music that the nucleus hears: cell-cell contact signaling and the modulation of gene activity. 2009, Pubmed
McCrea, Developmental functions of the P120-catenin sub-family. 2007, Pubmed
McMahon, Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis. 1989, Pubmed , Xenbase
Miyagishi, Regulation of Lef-mediated transcription and p53-dependent pathway by associating beta-catenin with CBP/p300. 2000, Pubmed
Nelson, Regulation of cell-cell adhesion by the cadherin-catenin complex. 2008, Pubmed
Nelson, Convergence of Wnt, beta-catenin, and cadherin pathways. 2004, Pubmed
Niessen, Another job for the talented p120-catenin. 2006, Pubmed
Nusse, Wnt signaling. 2012, Pubmed
Nusse, A versatile transcriptional effector of Wingless signaling. 1997, Pubmed
Nusse, Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. 1982, Pubmed
Nüsslein-Volhard, Mutations affecting segment number and polarity in Drosophila. 1980, Pubmed
Oh, GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis. 2009, Pubmed
Ozawa, The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. 1989, Pubmed
Park, Frodo links Dishevelled to the p120-catenin/Kaiso pathway: distinct catenin subfamilies promote Wnt signals. 2006, Pubmed , Xenbase
Park, Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets. 2005, Pubmed , Xenbase
Pieters, Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling. 2012, Pubmed
Pieters, Functions of p120ctn in development and disease. 2012, Pubmed
Pokutta, Biochemical and structural analysis of alpha-catenin in cell-cell contacts. 2008, Pubmed
Polakis, Wnt signaling in cancer. 2012, Pubmed
Porfiri, Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin. 1997, Pubmed
Reynolds, Emerging roles for p120-catenin in cell adhesion and cancer. 2004, Pubmed
Reynolds, Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer. 2004, Pubmed
Rijsewijk, Transfection of the int-1 mammary oncogene in cuboidal RAC mammary cell line results in morphological transformation and tumorigenicity. 1987, Pubmed
Rodova, Regulation of the rapsyn promoter by kaiso and delta-catenin. 2004, Pubmed
Ruzov, The non-methylated DNA-binding function of Kaiso is not required in early Xenopus laevis development. 2009, Pubmed , Xenbase
Saito, Classical and desmosomal cadherins at a glance. 2012, Pubmed
Schmidt, Plakophilins 1a and 1b: widespread nuclear proteins recruited in specific epithelial cells as desmosomal plaque components. 1997, Pubmed , Xenbase
Scott, Cinderella no longer: alpha-catenin steps out of cadherin's shadow. 2006, Pubmed
Shapiro, Structure and biochemistry of cadherins and catenins. 2009, Pubmed
Slorach, Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization. 2011, Pubmed
Sobolik-Delmaire, Plakophilin-1 localizes to the nucleus and interacts with single-stranded DNA. 2010, Pubmed
South, Lack of plakophilin 1 increases keratinocyte migration and reduces desmosome stability. 2003, Pubmed
Sylvie, The role of Wnt in cell signaling and cell adhesion during early vertebrate development. 2011, Pubmed
Tan, Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells. 2001, Pubmed
Thompson, A new nuclear component of the Wnt signalling pathway. 2002, Pubmed
Ulrich, Wnt11 functions in gastrulation by controlling cell cohesion through Rab5c and E-cadherin. 2005, Pubmed
Vallin, Cloning and characterization of three Xenopus slug promoters reveal direct regulation by Lef/beta-catenin signaling. 2001, Pubmed , Xenbase
Varelas, The Hippo pathway regulates Wnt/beta-catenin signaling. 2010, Pubmed
Wieschaus, Autonomous requirements for the segment polarity gene armadillo during Drosophila embryogenesis. 1987, Pubmed
Wodarz, Wingless signaling modulates cadherin-mediated cell adhesion in Drosophila imaginal disc cells. 2006, Pubmed
Yanagawa, Accumulation of Armadillo induced by Wingless, Dishevelled, and dominant-negative Zeste-White 3 leads to elevated DE-cadherin in Drosophila clone 8 wing disc cells. 1997, Pubmed
Yanagisawa, p120 catenin is essential for mesenchymal cadherin-mediated regulation of cell motility and invasiveness. 2006, Pubmed
Yanagisawa, A p120 catenin isoform switch affects Rho activity, induces tumor cell invasion, and predicts metastatic disease. 2008, Pubmed
Yap, Making and breaking contacts: the cellular biology of cadherin regulation. 2007, Pubmed
Yook, Wnt-dependent regulation of the E-cadherin repressor snail. 2005, Pubmed , Xenbase
Zeng, Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions. 2008, Pubmed , Xenbase
Zhou, Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. 2004, Pubmed
Zhurinsky, Plakoglobin and beta-catenin: protein interactions, regulation and biological roles. 2000, Pubmed