XB-ART-48315
FEBS Lett
2014 Apr 17;5888:1372-8. doi: 10.1016/j.febslet.2013.12.023.
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Connexin hemichannel and pannexin channel electrophysiology: how do they differ?
Patel D
,
Zhang X
,
Veenstra RD
.
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Species referenced: Xenopus
Genes referenced: gja1 p2rx7 panx1 slco1a2
References [+] :
Abe,
Prevalent connexin 26 gene (GJB2) mutations in Japanese.
2000, Pubmed
Abe, Prevalent connexin 26 gene (GJB2) mutations in Japanese. 2000, Pubmed
Alberto, Is pannexin the pore associated with the P2X7 receptor? 2013, Pubmed
Alves, Are there functional gap junctions or junctional hemichannels in macrophages? 1996, Pubmed
Aylsworth, Influence of lipids on gap-junction-mediated intercellular communication between Chinese hamster cells in vitro. 1986, Pubmed
Bao, Pannexin membrane channels are mechanosensitive conduits for ATP. 2004, Pubmed , Xenbase
Baranova, The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. 2004, Pubmed
Barrio, Gap junctions formed by connexins 26 and 32 alone and in combination are differently affected by applied voltage. 1991, Pubmed , Xenbase
Beyer, Evidence that the gap junction protein connexin-43 is the ATP-induced pore of mouse macrophages. 1991, Pubmed
Beyer, Connexin43: a protein from rat heart homologous to a gap junction protein from liver. 1987, Pubmed
Beyer, Connexin family of gap junction proteins. 1990, Pubmed
Boassa, Pannexin1 channels contain a glycosylation site that targets the hexamer to the plasma membrane. 2007, Pubmed
Browne, P2X7 receptor channels allow direct permeation of nanometer-sized dyes. 2013, Pubmed
Bruzzone, Pannexins, a family of gap junction proteins expressed in brain. 2003, Pubmed , Xenbase
Bruzzone, Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes. 2005, Pubmed , Xenbase
Burt, Volatile anesthetics block intercellular communication between neonatal rat myocardial cells. 1989, Pubmed
Burt, Uncoupling of cardiac cells by doxyl stearic acids specificity and mechanism of action. 1989, Pubmed
Chekeni, Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. 2010, Pubmed
Coddou, Activation and regulation of purinergic P2X receptor channels. 2011, Pubmed
Contreras, Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture. 2002, Pubmed
Coutinho-Silva, P2Z purinoceptor-associated pores induced by extracellular ATP in macrophages and J774 cells. 1997, Pubmed
Dahl, Attempts to define functional domains of gap junction proteins with synthetic peptides. 1994, Pubmed , Xenbase
Dahl, Expression of functional cell-cell channels from cloned rat liver gap junction complementary DNA. 1987, Pubmed , Xenbase
Davidson, Reversible inhibition of intercellular junctional communication by glycyrrhetinic acid. 1986, Pubmed
de Groot, Conduction slowing by the gap junctional uncoupler carbenoxolone. 2003, Pubmed
Donaldson, Molecular solutions to mammalian lens transparency. 2001, Pubmed
Donnelly-Roberts, Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors. 2009, Pubmed
Ebihara, Effect of external magnesium and calcium on human connexin46 hemichannels. 2003, Pubmed , Xenbase
Eckert, Biophysical characterization of gap-junction channels in HeLa cells. 1993, Pubmed
Ek-Vitorin, Selectivity of connexin 43 channels is regulated through protein kinase C-dependent phosphorylation. 2006, Pubmed
Evans, Connexin mimetic peptides: specific inhibitors of gap-junctional intercellular communication. 2001, Pubmed
Faria, Pharmacological properties of a pore induced by raising intracellular Ca2+. 2009, Pubmed
Gerido, Aberrant hemichannel properties of Cx26 mutations causing skin disease and deafness. 2007, Pubmed , Xenbase
Gómez-Hernández, Molecular basis of calcium regulation in connexin-32 hemichannels. 2003, Pubmed , Xenbase
Guan, The sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells. 1997, Pubmed
Hanley, Transient P2X7 receptor activation triggers macrophage death independent of Toll-like receptors 2 and 4, caspase-1, and pannexin-1 proteins. 2012, Pubmed
Harks, Fenamates: a novel class of reversible gap junction blockers. 2001, Pubmed
Harris, Emerging issues of connexin channels: biophysics fills the gap. 2001, Pubmed
Janecke, GJB2 mutations in keratitis-ichthyosis-deafness syndrome including its fatal form. 2005, Pubmed
Jiang, Brilliant blue G selectively blocks ATP-gated rat P2X(7) receptors. 2000, Pubmed
John, Connexin-43 hemichannels opened by metabolic inhibition. 1999, Pubmed
Johnston, Interaction of anaesthetics with electrical synapses. 1980, Pubmed
Kar, Biological role of connexin intercellular channels and hemichannels. 2012, Pubmed
Kienitz, Pannexin 1 constitutes the large conductance cation channel of cardiac myocytes. 2011, Pubmed , Xenbase
Kirkton, Engineering biosynthetic excitable tissues from unexcitable cells for electrophysiological and cell therapy studies. 2011, Pubmed
Klapperstück, Functional evidence of distinct ATP activation sites at the human P2X(7) receptor. 2001, Pubmed , Xenbase
Kwon, Molecular dynamics simulations of the Cx26 hemichannel: evaluation of structural models with Brownian dynamics. 2011, Pubmed , Xenbase
Laird, Closing the gap on autosomal dominant connexin-26 and connexin-43 mutants linked to human disease. 2008, Pubmed
Li, Properties and regulation of gap junctional hemichannels in the plasma membranes of cultured cells. 1996, Pubmed
Locovei, Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex. 2007, Pubmed , Xenbase
Lohman, S-nitrosylation inhibits pannexin 1 channel function. 2012, Pubmed
Ma, Pannexin 1 forms an anion-selective channel. 2012, Pubmed
Manthey, Transfection and expression of exogenous connexins in mammalian cells. 2001, Pubmed
McSpadden, Electrotonic loading of anisotropic cardiac monolayers by unexcitable cells depends on connexin type and expression level. 2009, Pubmed
McSpadden, Size and ionic currents of unexcitable cells coupled to cardiomyocytes distinctly modulate cardiac action potential shape and pacemaking activity in micropatterned cell pairs. 2012, Pubmed
Mese, The Cx26-G45E mutation displays increased hemichannel activity in a mouse model of the lethal form of keratitis-ichthyosis-deafness syndrome. 2011, Pubmed
North, Molecular physiology of P2X receptors. 2002, Pubmed
Paul, Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes. 1991, Pubmed , Xenbase
Pelegrin, Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. 2006, Pubmed
Pfahnl, Gating of cx46 gap junction hemichannels by calcium and voltage. 1999, Pubmed , Xenbase
Pfenniger, Mutations in connexin genes and disease. 2011, Pubmed
Prochnow, Replacement of a single cysteine in the fourth transmembrane region of zebrafish pannexin 1 alters hemichannel gating behavior. 2009, Pubmed
Rackauskas, Gating properties of heterotypic gap junction channels formed of connexins 40, 43, and 45. 2007, Pubmed
Retamal, S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: induction by oxidant stress and reversal by reducing agents. 2006, Pubmed
Saez, Plasma membrane channels formed by connexins: their regulation and functions. 2003, Pubmed
Sáez, Connexin-based gap junction hemichannels: gating mechanisms. 2005, Pubmed
Sánchez, Differentially altered Ca2+ regulation and Ca2+ permeability in Cx26 hemichannels formed by the A40V and G45E mutations that cause keratitis ichthyosis deafness syndrome. 2010, Pubmed , Xenbase
Sandilos, Pannexin 1, an ATP release channel, is activated by caspase cleavage of its pore-associated C-terminal autoinhibitory region. 2012, Pubmed
Scemes, Lack of "hemichannel" activity in insulin-producing cells. 2008, Pubmed
Schachter, HEK293 human embryonic kidney cells endogenously express the P2Y1 and P2Y2 receptors. 1997, Pubmed
Silverman, Probenecid, a gout remedy, inhibits pannexin 1 channels. 2008, Pubmed , Xenbase
Sosinsky, Pannexin channels are not gap junction hemichannels. 2011, Pubmed
Spray, Functional connexin "hemichannels": a critical appraisal. 2006, Pubmed
Srinivas, Closure of gap junction channels by arylaminobenzoates. 2003, Pubmed
Sroka, The inhibitory effect of diphenyltin on gap junctional intercellular communication in HEK-293 cells is reduced by thioredoxin reductase 1. 2008, Pubmed
Stong, A novel mechanism for connexin 26 mutation linked deafness: cell death caused by leaky gap junction hemichannels. 2006, Pubmed
Surprenant, The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7). 1996, Pubmed
Thomas, HEK293 cell line: a vehicle for the expression of recombinant proteins. 2005, Pubmed
Traub, Immunochemical and electrophysiological characterization of murine connexin40 and -43 in mouse tissues and transfected human cells. 1994, Pubmed
Trexler, Rapid and direct effects of pH on connexins revealed by the connexin46 hemichannel preparation. 1999, Pubmed , Xenbase
Veenstra, Multiple connexins confer distinct regulatory and conductance properties of gap junctions in developing heart. 1992, Pubmed
Veenstra, Voltage clamp limitations of dual whole-cell gap junction current and voltage recordings. I. Conductance measurements. 2001, Pubmed
Virginio, Kinetics of cell lysis, dye uptake and permeability changes in cells expressing the rat P2X7 receptor. 1999, Pubmed
Wang, Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. 2013, Pubmed
Wang, Connexin mimetic peptides inhibit Cx43 hemichannel opening triggered by voltage and intracellular Ca2+ elevation. 2012, Pubmed
Wang, Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. 2007, Pubmed , Xenbase
Wang, The food dye FD&C Blue No. 1 is a selective inhibitor of the ATP release channel Panx1. 2013, Pubmed , Xenbase
Weingart, Electrical properties of the nexal membrane studied in rat ventricular cell pairs. 1986, Pubmed
Wicki-Stordeur, Pannexin 1 regulates postnatal neural stem and progenitor cell proliferation. 2012, Pubmed
Xu, Histone deacetylase inhibition reduces cardiac connexin43 expression and gap junction communication. 2013, Pubmed
Yan, The P2X7 receptor channel pore dilates under physiological ion conditions. 2008, Pubmed
Zampighi, Functional and morphological correlates of connexin50 expressed in Xenopus laevis oocytes. 1999, Pubmed , Xenbase
Zampighi, Distribution of connexin50 channels and hemichannels in lens fibers: a structural approach. 2003, Pubmed
Zhang, Conserved glycine at position 45 of major cochlear connexins constitutes a vital component of the Ca²⁺ sensor for gating of gap junction hemichannels. 2013, Pubmed
Zonta, Permeation pathway of homomeric connexin 26 and connexin 30 channels investigated by molecular dynamics. 2012, Pubmed