Fleig A , Chubanov V .

P01 GM078195 NIGMS NIH HHS

Aarts, A key role for TRPM7 channels in anoxic neuronal death. 2003, Pubmed

Aarts, A key role for TRPM7 channels in anoxic neuronal death. 2003, Pubmed
Abed, Importance of melastatin-like transient receptor potential 7 and cations (magnesium, calcium) in human osteoblast-like cell proliferation. 2007, Pubmed
Bessac, TRPM7 channel is sensitive to osmotic gradients in human kidney cells. 2007, Pubmed
Cahalan, Role of potassium and chloride channels in volume regulation by T lymphocytes. 1988, Pubmed
Castillo, Development and optimization of a high-throughput bioassay for TRPM7 ion channel inhibitors. 2010, Pubmed
Chen, TRPM7 regulates the migration of human nasopharyngeal carcinoma cell by mediating Ca(2+) influx. 2010, Pubmed
Chen, Blockade of TRPM7 channel activity and cell death by inhibitors of 5-lipoxygenase. 2010, Pubmed
Chokshi, Sensitivity of TRPM7 channels to Mg2+ characterized in cell-free patches of Jurkat T lymphocytes. 2012, Pubmed
Chokshi, Detailed examination of Mg2+ and pH sensitivity of human TRPM7 channels. 2012, Pubmed
Chokshi, 2-aminoethyl diphenyl borinate (2-APB) inhibits TRPM7 channels through an intracellular acidification mechanism. 2012, Pubmed
Chubanov, Hypomagnesemia with secondary hypocalcemia due to a missense mutation in the putative pore-forming region of TRPM6. 2007, Pubmed , Xenbase
Chubanov, Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia. 2004, Pubmed , Xenbase
Chubanov, Natural and synthetic modulators of SK (K(ca)2) potassium channels inhibit magnesium-dependent activity of the kinase-coupled cation channel TRPM7. 2012, Pubmed
Clark, The alpha-kinases TRPM6 and TRPM7, but not eEF-2 kinase, phosphorylate the assembly domain of myosin IIA, IIB and IIC. 2008, Pubmed
Clark, TRPM7, a novel regulator of actomyosin contractility and cell adhesion. 2006, Pubmed
Clark, Massive autophosphorylation of the Ser/Thr-rich domain controls protein kinase activity of TRPM6 and TRPM7. 2008, Pubmed
Clark, TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation. 2008, Pubmed
Coombes, Pathophysiologically relevant levels of hydrogen peroxide induce glutamate-independent neurodegeneration that involves activation of transient receptor potential melastatin 7 channels. 2011, Pubmed
Crawley, Identification of dimer interactions required for the catalytic activity of the TRPM7 alpha-kinase domain. 2009, Pubmed
Dai, The relation of magnesium and calcium intakes and a genetic polymorphism in the magnesium transporter to colorectal neoplasia risk. 2007, Pubmed
Deason-Towne, Identification of Ser/Thr phosphorylation sites in the C2-domain of phospholipase C γ2 (PLCγ2) using TRPM7-kinase. 2012, Pubmed
Deason-Towne, The Mg2+ transporter MagT1 partially rescues cell growth and Mg2+ uptake in cells lacking the channel-kinase TRPM7. 2011, Pubmed
Demeuse, TRPM7 channel is regulated by magnesium nucleotides via its kinase domain. 2006, Pubmed
Desai, Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis. 2012, Pubmed
Dorovkov, Phosphorylation of annexin A1 by TRPM7 kinase: a switch regulating the induction of an α-helix. 2011, Pubmed
Dorovkov, Phosphorylation of annexin I by TRPM7 channel-kinase. 2004, Pubmed
Drennan, Alpha-kinases: analysis of the family and comparison with conventional protein kinases. 2004, Pubmed
Du, TRPM7-mediated Ca2+ signals confer fibrogenesis in human atrial fibrillation. 2010, Pubmed
Elizondo, trpm7 regulation of in vivo cation homeostasis and kidney function involves stanniocalcin 1 and fgf23. 2010, Pubmed
Elizondo, Defective skeletogenesis with kidney stone formation in dwarf zebrafish mutant for trpm7. 2005, Pubmed
Fonfria, Tissue distribution profiles of the human TRPM cation channel family. 2006, Pubmed
Fujiwara, X-ray crystal structure of a TRPM assembly domain reveals an antiparallel four-stranded coiled-coil. 2008, Pubmed
Gao, EGF enhances the migration of cancer cells by up-regulation of TRPM7. 2011, Pubmed
Georgiev, TRPM channels mediate zinc homeostasis and cellular growth during Drosophila larval development. 2010, Pubmed
Gouadon, Differential effects of cyclosporin A and tacrolimus on magnesium influx in Caco2 cells. 2012, Pubmed
Gwanyanya, Magnesium-inhibited, TRPM6/7-like channel in cardiac myocytes: permeation of divalent cations and pH-mediated regulation. 2004, Pubmed
Hamill, Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. 1981, Pubmed
Hara, TRPM7 is not associated with amyotrophic lateral sclerosis-parkinsonism dementia complex in the Kii peninsula of Japan. 2010, Pubmed
He, Transient receptor potential melastatin 7 ion channels regulate magnesium homeostasis in vascular smooth muscle cells: role of angiotensin II. 2005, Pubmed
Hermosura, Dissociation of the store-operated calcium current I(CRAC) and the Mg-nucleotide-regulated metal ion current MagNuM. 2002, Pubmed
Hermosura, A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders. 2005, Pubmed
Hofmann, Drosophila TRPM channel is essential for the control of extracellular magnesium levels. 2010, Pubmed
Ikuma, Regulation of CFTR Cl- channel gating by ATP binding and hydrolysis. 2000, Pubmed
Inoue, Zinc-induced neurotoxicity mediated by transient receptor potential melastatin 7 channels. 2010, Pubmed
Jang, Quantitative analysis of TRP channel genes in mouse organs. 2012, Pubmed
Jiang, Potentiation of TRPM7 inward currents by protons. 2005, Pubmed
Jiang, Transient receptor potential melastatin 7-like current in human head and neck carcinoma cells: role in cell proliferation. 2007, Pubmed
Jiang, X-ray structure of a voltage-dependent K+ channel. 2003, Pubmed
Jin, Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. 2008, Pubmed
Jin, The channel kinase, TRPM7, is required for early embryonic development. 2012, Pubmed
Kerschbaum, Polyvalent cations as permeant probes of MIC and TRPM7 pores. 2003, Pubmed
Kim, Suppression of transient receptor potential melastatin 7 channel induces cell death in gastric cancer. 2008, Pubmed
Kim, Identification of the phosphorylation sites on intact TRPM7 channels from mammalian cells. 2012, Pubmed
Kim, Identification of TRPM7 channels in human intestinal interstitial cells of Cajal. 2009, Pubmed
Kolisek, SLC41A1 is a novel mammalian Mg2+ carrier. 2008, Pubmed , Xenbase
Kourie, ATP-sensitive voltage- and calcium-dependent chloride channels in sarcoplasmic reticulum vesicles from rabbit skeletal muscle. 1997, Pubmed
Kozak, MIC channels are inhibited by internal divalent cations but not ATP. 2003, Pubmed
Kozak, Distinct properties of CRAC and MIC channels in RBL cells. 2002, Pubmed
Krapivinsky, The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release. 2006, Pubmed
Kunert-Keil, Tissue-specific expression of TRP channel genes in the mouse and its variation in three different mouse strains. 2006, Pubmed
Kuras, KCa3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells. 2012, Pubmed
Lam, Differential expression of TRPM7 in rat hepatoma and embryonic and adult hepatocytes. 2012, Pubmed
Langeslag, Activation of TRPM7 channels by phospholipase C-coupled receptor agonists. 2007, Pubmed
Lévesque, Characterization of cadmium uptake and cytotoxicity in human osteoblast-like MG-63 cells. 2008, Pubmed
Li, Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7. 2006, Pubmed
Li, Second messenger role for Mg2+ revealed by human T-cell immunodeficiency. 2011, Pubmed
Li, Molecular determinants of Mg2+ and Ca2+ permeability and pH sensitivity in TRPM6 and TRPM7. 2007, Pubmed
Liu, Inhibition of transient receptor potential melastain 7 channel increases HSCs apoptosis induced by TRAIL. 2012, Pubmed
Liu, TRPM7 regulates gastrulation during vertebrate embryogenesis. 2011, Pubmed , Xenbase
Louvet, Magnesium prevents phosphate-induced calcification in human aortic vascular smooth muscle cells. 2013, Pubmed
Low, TRPM7 is required within zebrafish sensory neurons for the activation of touch-evoked escape behaviors. 2011, Pubmed , Xenbase
Macianskiene, Inhibition of the magnesium-sensitive TRPM7-like channel in cardiac myocytes by nonhydrolysable GTP analogs: involvement of phosphoinositide metabolism. 2008, Pubmed
Macianskiene, Characterization of Mg²⁺-regulated TRPM7-like current in human atrial myocytes. 2012, Pubmed
Madsen, Charge-site-dependent dissociation of hydrogen-rich radical peptide cations upon vacuum UV photoexcitation. 2012, Pubmed
Martineau, Involvement of transient receptor potential melastatin-related 7 (TRPM7) channels in cadmium uptake and cytotoxicity in MC3T3-E1 osteoblasts. 2010, Pubmed
Mathes, Calcium release-activated calcium current (ICRAC) is a direct target for sphingosine. 1998, Pubmed
Matsushita, Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of TRPM7/ChaK1. 2005, Pubmed
McNeill, Cell death of melanophores in zebrafish trpm7 mutant embryos depends on melanin synthesis. 2007, Pubmed
Mederos y Schnitzler, Evolutionary determinants of divergent calcium selectivity of TRPM channels. 2008, Pubmed
Meng, TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathway. 2013, Pubmed
Meyer, Cell swelling activates ATP-dependent voltage-gated chloride channels in M-1 mouse cortical collecting duct cells. 1996, Pubmed
Middelbeek, TRPM7 is required for breast tumor cell metastasis. 2012, Pubmed
Monteilh-Zoller, TRPM7 provides an ion channel mechanism for cellular entry of trace metal ions. 2003, Pubmed
Nadler, LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability. 2001, Pubmed
Ng, Retrovirus-mediated siRNA targeting TRPM7 gene induces apoptosis in RBL-2H3 cells. 2012, Pubmed
Numata, TRPM7 is a stretch- and swelling-activated cation channel involved in volume regulation in human epithelial cells. 2007, Pubmed
Numata, Molecular determinants of sensitivity and conductivity of human TRPM7 to Mg2+ and Ca2+. 2008, Pubmed
Oancea, Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow. 2006, Pubmed
Penner, The Mg2+ and Mg(2+)-nucleotide-regulated channel-kinase TRPM7. 2007, Pubmed
Perraud, ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. 2001, Pubmed
Perraud, The channel-kinase TRPM7 regulates phosphorylation of the translational factor eEF2 via eEF2-k. 2011, Pubmed
Prakriya, Separation and characterization of currents through store-operated CRAC channels and Mg2+-inhibited cation (MIC) channels. 2002, Pubmed
Qin, Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels. 2013, Pubmed
Romero, Gene variation of the transient receptor potential cation channel, subfamily M, member 7 (TRPM7), and risk of incident ischemic stroke: prospective, nested, case-control study. 2009, Pubmed
Runnels, The TRPM7 channel is inactivated by PIP(2) hydrolysis. 2002, Pubmed
Runnels, TRPM6 and TRPM7: A Mul-TRP-PLIK-cation of channel functions. 2011, Pubmed
Runnels, TRP-PLIK, a bifunctional protein with kinase and ion channel activities. 2001, Pubmed
Ryazanov, Alpha-kinases: a new class of protein kinases with a novel catalytic domain. 1999, Pubmed
Ryazanov, Elongation factor-2 kinase and its newly discovered relatives. 2002, Pubmed
Ryazanova, TRPM7 is essential for Mg(2+) homeostasis in mammals. 2010, Pubmed
Ryazanova, Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel. 2004, Pubmed
Rybarczyk, Transient receptor potential melastatin-related 7 channel is overexpressed in human pancreatic ductal adenocarcinomas and regulates human pancreatic cancer cell migration. 2012, Pubmed
Sah, Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization. 2013, Pubmed
Sahmoun, Does a higher ratio of serum calcium to magnesium increase the risk for postmenopausal breast cancer? 2010, Pubmed
Sahni, SLC41A2 encodes a plasma-membrane Mg2+ transporter. 2007, Pubmed
Sahni, TRPM7 regulates quiescent/proliferative metabolic transitions in lymphocytes. 2010, Pubmed
Schlingmann, Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family. 2002, Pubmed
Schmitz, The channel kinases TRPM6 and TRPM7 are functionally nonredundant. 2005, Pubmed
Schmitz, Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7. 2003, Pubmed
Schweigel, Expression and functional activity of the Na/Mg exchanger, TRPM7 and MagT1 are changed to regulate Mg homeostasis and transport in rumen epithelial cells. 2008, Pubmed
Singh, The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels. 2010, Pubmed
Sontia, Downregulation of renal TRPM7 and increased inflammation and fibrosis in aldosterone-infused mice: effects of magnesium. 2008, Pubmed
Staaf, Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons. 2010, Pubmed
Su, TRPM7 activates m-calpain by stress-dependent stimulation of p38 MAPK and c-Jun N-terminal kinase. 2010, Pubmed
Su, TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpain. 2006, Pubmed
Su, TRPM7 regulates polarized cell movements. 2011, Pubmed
Sun, Increase in serum Ca2+/Mg2+ ratio promotes proliferation of prostate cancer cells by activating TRPM7 channels. 2013, Pubmed
Sun, Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia. 2009, Pubmed
Takezawa, Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain. 2004, Pubmed
Tani, Cell cycle-dependent regulation of store-operated I(CRAC) and Mg2+-nucleotide-regulated MagNuM (TRPM7) currents. 2007, Pubmed
Tarasov, Metabolic regulation of the pancreatic beta-cell ATP-sensitive K+ channel: a pas de deux. 2004, Pubmed
Teramoto, Differential regulation of TRPM channels governs electrolyte homeostasis in the C. elegans intestine. 2005, Pubmed
Teramoto, Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel. 2010, Pubmed
Tian, NGF-induced reduction of an outward-rectifying TRPM7-like current in rat CA1 hippocampal neurons. 2007, Pubmed
Touyz, Differential regulation of transient receptor potential melastatin 6 and 7 cation channels by ANG II in vascular smooth muscle cells from spontaneously hypertensive rats. 2006, Pubmed
Tseveleki, Comparative gene expression analysis in mouse models for multiple sclerosis, Alzheimer's disease and stroke for identifying commonly regulated and disease-specific gene changes. 2010, Pubmed
Vandewauw, Systematic and quantitative mRNA expression analysis of TRP channel genes at the single trigeminal and dorsal root ganglion level in mouse. 2013, Pubmed
Venkatachalam, TRP channels. 2007, Pubmed
Voets, TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption. 2004, Pubmed
Walder, Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia. 2002, Pubmed
Wang, Distribution profiles of transient receptor potential melastatin-related and vanilloid-related channels in prostatic tissue in rat. 2007, Pubmed
Wei, Calcium flickers steer cell migration. 2009, Pubmed
Wei, TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations. 2007, Pubmed
Yamaguchi, Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity. 2001, Pubmed
Yang, Functional expression of transient receptor potential melastatin- and vanilloid-related channels in pulmonary arterial and aortic smooth muscle. 2006, Pubmed
Yee, Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer. 2011, Pubmed
Yogi, Transient receptor potential melastatin 7 (TRPM7) cation channels, magnesium and the vascular system in hypertension. 2011, Pubmed
Yogi, Bradykinin regulates calpain and proinflammatory signaling through TRPM7-sensitive pathways in vascular smooth muscle cells. 2009, Pubmed
Yu, TRPM7 is regulated by halides through its kinase domain. 2013, Pubmed
Zhang, Upregulation of TRPM7 channels by angiotensin II triggers phenotypic switching of vascular smooth muscle cells of ascending aorta. 2012, Pubmed
Zhang, Hypoxia induces an increase in intracellular magnesium via transient receptor potential melastatin 7 (TRPM7) channels in rat hippocampal neurons in vitro. 2011, Pubmed
Zhang, Evidence for functional expression of TRPM7 channels in human atrial myocytes. 2012, Pubmed
Zierler, Waixenicin A inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channels. 2011, Pubmed