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Dev Genes Evol
2015 Apr 01;2252:105-11. doi: 10.1007/s00427-015-0497-0.
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Developmental expression analysis of Na, K-ATPase α subunits in Xenopus.
Rahman MM
,
Tae HJ
,
Cho HS
,
Shin GW
,
Park BY
.
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Na, K-ATPase is an integral membrane protein complex responsible for maintaining the ionic gradients of Na(+) and K(+) across the plasma membrane and has a variety of cellular functions including neuronal activity. Studies in several organisms have shown that this protein complex regulates multiple aspects of embryonic development and is responsible for the pathogenesis of several human diseases. Here, we report the cloning and expression of Na, K-ATPase α2 (atp1a2) and α3 (atp1a3) subunits during Xenopus development and compare the expression patterns of each subunit. Using in situ hybridization in whole embryos and on sections, we show that all three α subunits are co-expressed in the pronephric kidney, with varying expression in neurogenic derivatives. The atp1a2 has a unique expression in the ependymal cell layer of the developing brain that is not shared with other α subunits. The Na, K-ATPase α1 (atp1a1), and atp1a3 share many expression domains in placode derivatives, including the otic vesicle, lens, ganglion of the anterodorsal lateral line nerve, and ganglia of the facial and anteroventral lateral line nerve and olfactory cells. All the subunits share a common expression domain, the myocardium.
Blanco,
Na,K-ATPase subunit heterogeneity as a mechanism for tissue-specific ion regulation.
2005, Pubmed
Blanco,
Na,K-ATPase subunit heterogeneity as a mechanism for tissue-specific ion regulation.
2005,
Pubmed
Blanco,
Functional expression of the alpha 2 and alpha 3 isoforms of the Na,K-ATPase in baculovirus-infected insect cells.
1993,
Pubmed
Crambert,
Transport and pharmacological properties of nine different human Na, K-ATPase isozymes.
2000,
Pubmed
,
Xenbase
Davies,
Primary sequence and developmental expression pattern of mRNAs and protein for an alpha1 subunit of the sodium pump cloned from the neural plate of Xenopus laevis.
1996,
Pubmed
,
Xenbase
de Carvalho Aguiar,
Mutations in the Na+/K+ -ATPase alpha3 gene ATP1A3 are associated with rapid-onset dystonia parkinsonism.
2004,
Pubmed
De Fusco,
Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2.
2003,
Pubmed
Doganli,
The α2Na+/K+-ATPase is critical for skeletal and heart muscle function in zebrafish.
2012,
Pubmed
Eid,
Xenopus Na,K-ATPase: primary sequence of the beta2 subunit and in situ localization of alpha1, beta1, and gamma expression during pronephric kidney development.
2001,
Pubmed
,
Xenbase
Glynn,
Annual review prize lecture. 'All hands to the sodium pump'.
1993,
Pubmed
Heinzen,
De novo mutations in ATP1A3 cause alternating hemiplegia of childhood.
2012,
Pubmed
Henriksen,
Molecular cloning and characterization of porcine Na⁺/K⁺-ATPase isoforms α1, α2, α3 and the ATP1A3 promoter.
2013,
Pubmed
Mata,
Differential distribution of (Na,K)-ATPase alpha isoform mRNAs in the peripheral nervous system.
1991,
Pubmed
McGrail,
Immunofluorescent localization of three Na,K-ATPase isozymes in the rat central nervous system: both neurons and glia can express more than one Na,K-ATPase.
1991,
Pubmed
Pearson,
Generalized neighbor-joining: more reliable phylogenetic tree reconstruction.
1999,
Pubmed
Schlosser,
Development of neurogenic placodes in Xenopus laevis.
2000,
Pubmed
,
Xenbase
Schneider,
Tissue specificity, localization in brain, and cell-free translation of mRNA encoding the A3 isoform of Na+,K+-ATPase.
1988,
Pubmed
Shull,
Molecular cloning of three distinct forms of the Na+,K+-ATPase alpha-subunit from rat brain.
1986,
Pubmed
Thompson,
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.
1994,
Pubmed
Wang,
Regional expression of sodium pump subunits isoforms and Na+-Ca++ exchanger in the human heart.
1996,
Pubmed
