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Follicle Online: an integrated database of follicle assembly, development and ovulation.
Hua J
,
Xu B
,
Yang Y
,
Ban R
,
Iqbal F
,
Cooke HJ
,
Zhang Y
,
Shi Q
.
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Folliculogenesis is an important part of ovarian function as it provides the oocytes for female reproductive life. Characterizing genes/proteins involved in folliculogenesis is fundamental for understanding the mechanisms associated with this biological function and to cure the diseases associated with folliculogenesis. A large number of genes/proteins associated with folliculogenesis have been identified from different species. However, no dedicated public resource is currently available for folliculogenesis-related genes/proteins that are validated by experiments. Here, we are reporting a database 'Follicle Online' that provides the experimentally validated gene/protein map of the folliculogenesis in a number of species. Follicle Online is a web-based database system for storing and retrieving folliculogenesis-related experimental data. It provides detailed information for 580 genes/proteins (from 23 model organisms, including Homo sapiens, Mus musculus, Rattus norvegicus, Mesocricetus auratus, Bos Taurus, Drosophila and Xenopus laevis) that have been reported to be involved in folliculogenesis, POF (premature ovarian failure) and PCOS (polycystic ovary syndrome). The literature was manually curated from more than 43,000 published articles (till 1 March 2014). The Follicle Online database is implemented in PHP + MySQL + JavaScript and this user-friendly web application provides access to the stored data. In summary, we have developed a centralized database that provides users with comprehensive information about genes/proteins involved in folliculogenesis. This database can be accessed freely and all the stored data can be viewed without any registration. Database URL: http://mcg.ustc.edu.cn/sdap1/follicle/index.php
Figure 2. (A) Screen shots of user interfaceâsimple search. Simple search query using one of the six options provided e.g. Gene Name. (B) Screen shots of user interfaceâadvance search. The search mode is an advanced search with multiple parameters that permits retrieval of very fine subsets of data.
Figure 3. Screen shots of user interfaceâresult page. Collage of some of the results produced via clicking the âBrowseâ button in both âSimpleâ and âAdvancedâ search options.
Figure 4. An example of potential protein network of folliculogenesis. The proteins in square frame (ESR1, PDK1, AKT1 and PTEN) are reported to participate in folliculogenesis. The proteins in circle are predicted to interact with the four proteins (in square boxes) either directly or indirectly. Red lines represents the experimentally verified interactions. Although the grey line shows the predicted interactions of proteins by our database.
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