XB-ART-50911
Annu Rev Cell Dev Biol
2014 Jan 01;30:581-613. doi: 10.1146/annurev-cellbio-100913-013027.
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Zygotic genome activation during the maternal-to-zygotic transition.
Lee MT
,
Bonneau AR
,
Giraldez AJ
.
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Embryogenesis depends on a highly coordinated cascade of genetically encoded events. In animals, maternal factors contributed by the egg cytoplasm initially control development, whereas the zygotic nuclear genome is quiescent. Subsequently, the genome is activated, embryonic gene products are mobilized, and maternal factors are cleared. This transfer of developmental control is called the maternal-to-zygotic transition (MZT). In this review, we discuss recent advances toward understanding the scope, timing, and mechanisms that underlie zygotic genome activation at the MZT in animals. We describe high-throughput techniques to measure the embryonic transcriptome and explore how regulation of the cell cycle, chromatin, and transcription factors together elicits specific patterns of embryonic gene expression. Finally, we illustrate the interplay between zygotic transcription and maternal clearance and show how these two activities combine to reprogram two terminally differentiated gametes into a totipotent embryo.
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???displayArticle.grants??? [+]
F32HD071697-03 NICHD NIH HHS , R01 GM081602 NIGMS NIH HHS , R01-GM103789-2 NIGMS NIH HHS , R01-GM081602-06A1 NIGMS NIH HHS , R01-GM102251-2 NIGMS NIH HHS , R01 GM103789 NIGMS NIH HHS , T32GM007499 NIGMS NIH HHS , R01 GM101108 NIGMS NIH HHS , R01-HD074078-3 NICHD NIH HHS , R01 GM102251 NIGMS NIH HHS , R01 HD074078 NICHD NIH HHS , R21-HD073768-2 NICHD NIH HHS , R01-GM101108-3 NIGMS NIH HHS
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