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XB-ART-51471
J Nat Prod 2015 Nov 25;7811:2537-44. doi: 10.1021/acs.jnatprod.5b00457.
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Curare Alkaloids: Constituents of a Matis Dart Poison.

Malca Garcia GR , Hennig L , Shelukhina IV , Kudryavtsev DS , Bussmann RW , Tsetlin VI , Giannis A .


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A phytochemical study of dart and arrow poison from the Matis tribe led to the identification of D-(-)-quinic acid, L-malic acid, ethyldimethylamine, magnoflorine, and five new bisbenzyltetrahydroisoquinoline alkaloids (BBIQAs), 1-5. D-Tubocurarine could not be identified among these products. BBIQA (3) contains a unique linkage at C-8 and C-11'. All structures were characterized by a combination of NMR and HRESIMS data. The effects of Matis poison and individual BBIQAs (1-3) on rat muscle nAChR expressed in Xenopus oocytes have been investigated using the two-electrode voltage clamp technique.

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