XB-ART-53036
FEBS J
2017 Jan 01;2842:211-217. doi: 10.1111/febs.13988.
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Nuclear transplantation, the conservation of the genome, and prospects for cell replacement.
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Initial nuclear transplantation experiments in Xenopus eggs provided the first evidence for the conservation of the genome after cellular differentiation. This Discovery-in-Context Review recounts the early experiments that led to successful nuclear transfer in amphibians and the establishment of totipotency of a differentiated cell and shows how these discoveries paved the way for similar cloning experiments in other organisms.
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