XB-ART-53080
Curr Pathobiol Rep
2017 Mar 01;51:79-92. doi: 10.1007/s40139-017-0128-8.
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Modeling human craniofacial disorders in Xenopus.
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PURPOSE OF REVIEW: Craniofacial disorders are among the most common human birth defects and present an enormous health care and social burden. The development of animal models has been instrumental to investigate fundamental questions in craniofacial biology and this knowledge is critical to understand the etiology and pathogenesis of these disorders. RECENT FINDINGS: The vast majority of craniofacial disorders arise from abnormal development of the neural crest, a multipotent and migratory cell population. Therefore, defining the pathogenesis of these conditions starts with a deep understanding of the mechanisms that preside over neural crest formation and its role in craniofacial development. SUMMARY: This review discusses several studies using Xenopus embryos to model human craniofacial conditions, and emphasizes the strength of this system to inform important biological processes as they relate to human craniofacial development and disease.
???displayArticle.pubmedLink??? 28255527
???displayArticle.pmcLink??? PMC5327820
???displayArticle.link??? Curr Pathobiol Rep
???displayArticle.grants??? [+]
R01 DE025468 NIDCR NIH HHS, R01 DE025806 NIDCR NIH HHS
GO keywords: face development
???displayArticle.disOnts??? Andersen-Tawil syndrome [+]
campomelic dysplasia
orofacial cleft
fetal alcohol syndrome
CHARGE syndrome
Smith-Magenis syndrome
DiGeorge syndrome
Ehlers-Danlos syndrome
Nager acrofacial dysostosis
???displayArticle.omims??? CAMPOMELIC DYSPLASIA [+]
ACROFACIAL DYSOSTOSIS 1, NAGER TYPE; AFD1
ANDERSEN CARDIODYSRHYTHMIC PERIODIC PARALYSIS
SMITH-MAGENIS SYNDROME; SMS
DIGEORGE SYNDROME; DGS
CHARGE SYNDROME
EHLERS-DANLOS SYNDROME, MUSCULOCONTRACTURAL TYPE, 1; EDSMC1
HAMAMY SYNDROME; HMMS
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