Scherer D , Schworm B , Seyler C , Xynogalos P , Scholz EP , Thomas D , Katus HA , Zitron E .

Bartos, Ion Channels in the Heart. 2015, Pubmed

Bartos, Ion Channels in the Heart. 2015, Pubmed
Beuckelmann, Alterations of K+ currents in isolated human ventricular myocytes from patients with terminal heart failure. 1993, Pubmed
Chi, An open-labeled, randomized, multicenter phase IIa study of gambogic acid injection for advanced malignant tumors. 2013, Pubmed
de Boer, The anti-protozoal drug pentamidine blocks KIR2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel. 2010, Pubmed
Dhamoon, Unique Kir2.x properties determine regional and species differences in the cardiac inward rectifier K+ current. 2004, Pubmed
Du, Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators. 2004, Pubmed , Xenbase
Fakler, Strong voltage-dependent inward rectification of inward rectifier K+ channels is caused by intracellular spermine. 1995, Pubmed , Xenbase
Felth, Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system. 2013, Pubmed
Ferrer, Carvedilol inhibits Kir2.3 channels by interference with PIP₂-channel interaction. 2011, Pubmed
Ficker, Spermine and spermidine as gating molecules for inward rectifier K+ channels. 1994, Pubmed , Xenbase
Guizzunti, Subcellular localization and activity of gambogic acid. 2012, Pubmed
Huang, Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma. 1998, Pubmed , Xenbase
Janse, Electrophysiological changes in heart failure and their relationship to arrhythmogenesis. 2004, Pubmed
Kääb, Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. 1996, Pubmed
Karle, Human cardiac inwardly-rectifying K+ channel Kir(2.1b) is inhibited by direct protein kinase C-dependent regulation in human isolated cardiomyocytes and in an expression system. 2002, Pubmed , Xenbase
Kasibhatla, A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid. 2005, Pubmed
Kiesecker, Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1. 2006, Pubmed , Xenbase
Koepple, Dual Mechanism for Inhibition of Inwardly Rectifying Kir2.x Channels by Quinidine Involving Direct Pore Block and PIP2-interference. 2017, Pubmed , Xenbase
Kurata, The role of the cytoplasmic pore in inward rectification of Kir2.1 channels. 2007, Pubmed
Li, Gambogic acid is a tissue-specific proteasome inhibitor in vitro and in vivo. 2013, Pubmed
Liu, Gambogic acid suppresses pressure overload cardiac hypertrophy in rats. 2013, Pubmed
Logothetis, Phosphoinositide-mediated gating of inwardly rectifying K(+) channels. 2007, Pubmed
Lopatin, Inward rectifiers in the heart: an update on I(K1). 2001, Pubmed
López-Izquierdo, The antimalarial drug mefloquine inhibits cardiac inward rectifier K+ channels: evidence for interference in PIP2-channel interaction. 2011, Pubmed
López-Izquierdo, Thiopental inhibits function of different inward rectifying potassium channel isoforms by a similar mechanism. 2010, Pubmed
López-Izquierdo, Mechanisms for Kir channel inhibition by quinacrine: acute pore block of Kir2.x channels and interference in PIP2 interaction with Kir2.x and Kir6.2 channels. 2011, Pubmed
Lü, Structural Basis for Differences in Dynamics Induced by Leu Versus Ile Residues in the CD Loop of Kir Channels. 2016, Pubmed , Xenbase
Madeja, Follicular tissues reduce drug effects on ion channels in oocytes of Xenopus laevis. 1997, Pubmed , Xenbase
Melnyk, Comparison of ion channel distribution and expression in cardiomyocytes of canine pulmonary veins versus left atrium. 2005, Pubmed
Noujaim, Specific residues of the cytoplasmic domains of cardiac inward rectifier potassium channels are effective antifibrillatory targets. 2010, Pubmed
Pandey, Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway. 2007, Pubmed
Plaster, Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome. 2001, Pubmed , Xenbase
Ponce-Balbuena, Tamoxifen inhibits inward rectifier K+ 2.x family of inward rectifier channels by interfering with phosphatidylinositol 4,5-bisphosphate-channel interactions. 2009, Pubmed
Preisig-Müller, Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome. 2002, Pubmed , Xenbase
Priori, Inherited dysfunction of sarcoplasmic reticulum Ca2+ handling and arrhythmogenesis. 2011, Pubmed
Rodríguez-Menchaca, The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel. 2008, Pubmed
Scherer, Inhibition of Cardiac Kir Current (IK1) by Protein Kinase C Critically Depends on PKCβ and Kir2.2. 2016, Pubmed , Xenbase
Schram, Barium block of Kir2 and human cardiac inward rectifier currents: evidence for subunit-heteromeric contribution to native currents. 2003, Pubmed , Xenbase
Shi, Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent Bcr-Abl downregulation. 2014, Pubmed
Tristani-Firouzi, Functional and clinical characterization of KCNJ2 mutations associated with LQT7 (Andersen syndrome). 2002, Pubmed , Xenbase
van der Heyden, Toward specific cardiac I(K1) modulators for in vivo application: old drugs point the way. 2011, Pubmed
van der Heyden, Inhibition of cardiac inward rectifier currents by cationic amphiphilic drugs. 2013, Pubmed
Wang, Differential distribution of inward rectifier potassium channel transcripts in human atrium versus ventricle. 1998, Pubmed
Witchel, Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes. 2002, Pubmed , Xenbase
Xiao, Localization of PIP2 activation gate in inward rectifier K+ channels. 2003, Pubmed , Xenbase
Xynogalos, Class III antiarrhythmic drug dronedarone inhibits cardiac inwardly rectifying Kir2.1 channels through binding at residue E224. 2014, Pubmed , Xenbase
Zaks-Makhina, Specific and slow inhibition of the kir2.1 K+ channel by gambogic acid. 2009, Pubmed
Zaritsky, The consequences of disrupting cardiac inwardly rectifying K(+) current (I(K1)) as revealed by the targeted deletion of the murine Kir2.1 and Kir2.2 genes. 2001, Pubmed
Zhai, Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins. 2008, Pubmed
Zhang, Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay. 2004, Pubmed
Zhao, Viability inhibition effect of gambogic acid combined with cisplatin on osteosarcoma cells via mitochondria-independent apoptotic pathway. 2013, Pubmed
Zobel, Molecular dissection of the inward rectifier potassium current (IK1) in rabbit cardiomyocytes: evidence for heteromeric co-assembly of Kir2.1 and Kir2.2. 2003, Pubmed