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Linker histones: novel insights into structure-specific recognition of the nucleosome.
Cutter AR
,
Hayes JJ
.
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Linker histones (H1s) are a primary component of metazoan chromatin, fulfilling numerous functions, both in vitro and in vivo, including stabilizing the wrapping of DNA around the nucleosome, promoting folding and assembly of higher order chromatin structures, influencing nucleosome spacing on DNA, and regulating specific gene expression. However, many molecular details of how H1 binds to nucleosomes and recognizes unique structural features on the nucleosome surface remain undefined. Numerous, confounding studies are complicated not only by experimental limitations, but the use of different linker histone isoforms and nucleosome constructions. This review summarizes the decades of research that has resulted in several models of H1 association with nucleosomes, with a focus on recent advances that suggest multiple modes of H1 interaction in chromatin, while highlighting the remaining questions.
Allan,
The structure of histone H1 and its location in chromatin.
1980, Pubmed
Allan,
The structure of histone H1 and its location in chromatin.
1980,
Pubmed
Allan,
Roles of H1 domains in determining higher order chromatin structure and H1 location.
1986,
Pubmed
Böhm,
Sequence conservation in the N-terminal domain of histone H1.
1985,
Pubmed
Bradbury,
Studies on the role and mode of operation of the very-lysine-rich histone H1 (F1) in eukaryote chromatin. The properties of the N-terminal and C-terminal halves of histone H1.
1975,
Pubmed
Brown,
Mapping the interaction surface of linker histone H1(0) with the nucleosome of native chromatin in vivo.
2006,
Pubmed
Caterino,
Nucleosome linker DNA contacts and induces specific folding of the intrinsically disordered H1 carboxyl-terminal domain.
2011,
Pubmed
,
Xenbase
Cerf,
Homo- and heteronuclear two-dimensional NMR studies of the globular domain of histone H1: sequential assignment and secondary structure.
1993,
Pubmed
Cerf,
Homo- and heteronuclear two-dimensional NMR studies of the globular domain of histone H1: full assignment, tertiary structure, and comparison with the globular domain of histone H5.
1994,
Pubmed
Clark,
Alpha-helix in the carboxy-terminal domains of histones H1 and H5.
1988,
Pubmed
Clark,
Salt-dependent co-operative interaction of histone H1 with linear DNA.
1986,
Pubmed
Correll,
Short nucleosome repeats impose rotational modulations on chromatin fibre folding.
2012,
Pubmed
Crane-Robinson,
Where is the globular domain of linker histone located on the nucleosome?
1997,
Pubmed
Cutter,
A brief review of nucleosome structure.
2015,
Pubmed
Dorigo,
Nucleosome arrays reveal the two-start organization of the chromatin fiber.
2004,
Pubmed
,
Xenbase
Draves,
Co-operative binding of the globular domain of histone H5 to DNA.
1992,
Pubmed
Fan,
Complex of linker histone H5 with the nucleosome and its implications for chromatin packing.
2006,
Pubmed
Fang,
DNA and nucleosomes direct distinct folding of a linker histone H1 C-terminal domain.
2012,
Pubmed
,
Xenbase
Flanagan,
Photobleaching studies reveal that a single amino acid polymorphism is responsible for the differential binding affinities of linker histone subtypes H1.1 and H1.5.
2016,
Pubmed
George,
Nucleosome interaction surface of linker histone H1c is distinct from that of H1(0).
2010,
Pubmed
Goytisolo,
Identification of two DNA-binding sites on the globular domain of histone H5.
1996,
Pubmed
Graziano,
Histone H1 is located in the interior of the chromatin 30-nm filament.
1994,
Pubmed
Grigoryev,
Hierarchical looping of zigzag nucleosome chains in metaphase chromosomes.
2016,
Pubmed
Hamiche,
Linker histone-dependent DNA structure in linear mononucleosomes.
1996,
Pubmed
Hansen,
Intrinsic protein disorder, amino acid composition, and histone terminal domains.
2006,
Pubmed
Happel,
Histone H1 and its isoforms: contribution to chromatin structure and function.
2009,
Pubmed
Hayashi,
Tetrahymena histone H1. Isolation and amino acid sequence lacking the central hydrophobic domain conserved in other H1 histones.
1987,
Pubmed
Hayes,
Site-directed cleavage of DNA by a linker histone--Fe(II) EDTA conjugate: localization of a globular domain binding site within a nucleosome.
1996,
Pubmed
,
Xenbase
Hayes,
A putative DNA binding surface in the globular domain of a linker histone is not essential for specific binding to the nucleosome.
1996,
Pubmed
,
Xenbase
Hayes,
Preferential and asymmetric interaction of linker histones with 5S DNA in the nucleosome.
1993,
Pubmed
,
Xenbase
Hendzel,
The C-terminal domain is the primary determinant of histone H1 binding to chromatin in vivo.
2004,
Pubmed
Hutchinson,
Interaction of chromatin with a histone H1 containing swapped N- and C-terminal domains.
2015,
Pubmed
Izzo,
The role of linker histone H1 modifications in the regulation of gene expression and chromatin dynamics.
2016,
Pubmed
Kalashnikova,
Linker histone H1.0 interacts with an extensive network of proteins found in the nucleolus.
2013,
Pubmed
Kalashnikova,
Linker histone H1 and protein-protein interactions.
2016,
Pubmed
Landsman,
Histone H1 in Saccharomyces cerevisiae: a double mystery solved?
1996,
Pubmed
Leng,
The preferential interactions of polylysine and polyarginine with specific base sequences in DNA.
1966,
Pubmed
Losa,
Involvement of the globular domain of histone H1 in the higher order structures of chromatin.
1984,
Pubmed
Lu,
Chromatin condensing functions of the linker histone C-terminal domain are mediated by specific amino acid composition and intrinsic protein disorder.
2009,
Pubmed
Lu,
Identification of specific functional subdomains within the linker histone H10 C-terminal domain.
2004,
Pubmed
Luque,
Dynamic condensation of linker histone C-terminal domain regulates chromatin structure.
2014,
Pubmed
Meyer,
From crystal and NMR structures, footprints and cryo-electron-micrographs to large and soft structures: nanoscale modeling of the nucleosomal stem.
2011,
Pubmed
Millán-Ariño,
Specificities and genomic distribution of somatic mammalian histone H1 subtypes.
2016,
Pubmed
Misteli,
Dynamic binding of histone H1 to chromatin in living cells.
2000,
Pubmed
Pan,
Role of H1 linker histones in mammalian development and stem cell differentiation.
2016,
Pubmed
Parseghian,
A compendium of the histone H1 family of somatic subtypes: an elusive cast of characters and their characteristics.
2001,
Pubmed
Pehrson,
Thymine dimer formation as a probe of the path of DNA in and between nucleosomes in intact chromatin.
1989,
Pubmed
Pruss,
An asymmetric model for the nucleosome: a binding site for linker histones inside the DNA gyres.
1996,
Pubmed
,
Xenbase
Ramakrishnan,
Crystal structure of globular domain of histone H5 and its implications for nucleosome binding.
1993,
Pubmed
Robinson,
EM measurements define the dimensions of the "30-nm" chromatin fiber: evidence for a compact, interdigitated structure.
2006,
Pubmed
Robinson,
Structure of the '30 nm' chromatin fibre: a key role for the linker histone.
2006,
Pubmed
Roque,
DNA-induced secondary structure of the carboxyl-terminal domain of histone H1.
2005,
Pubmed
Routh,
Nucleosome repeat length and linker histone stoichiometry determine chromatin fiber structure.
2008,
Pubmed
Schalch,
X-ray structure of a tetranucleosome and its implications for the chromatin fibre.
2005,
Pubmed
,
Xenbase
Simpson,
Structure of the chromatosome, a chromatin particle containing 160 base pairs of DNA and all the histones.
1978,
Pubmed
Song,
Cryo-EM study of the chromatin fiber reveals a double helix twisted by tetranucleosomal units.
2014,
Pubmed
,
Xenbase
Stasevich,
Dissecting the binding mechanism of the linker histone in live cells: an integrated FRAP analysis.
2010,
Pubmed
Staynov,
Footprinting of linker histones H5 and H1 on the nucleosome.
1988,
Pubmed
Syed,
Single-base resolution mapping of H1-nucleosome interactions and 3D organization of the nucleosome.
2010,
Pubmed
Szerlong,
Proteomic characterization of the nucleolar linker histone H1 interaction network.
2015,
Pubmed
Talbert,
A unified phylogeny-based nomenclature for histone variants.
2012,
Pubmed
Thoma,
Involvement of the domains of histones H1 and H5 in the structural organization of soluble chromatin.
1983,
Pubmed
Thoma,
Involvement of histone H1 in the organization of the nucleosome and of the salt-dependent superstructures of chromatin.
1979,
Pubmed
Thoma,
Influence of histone H1 on chromatin structure.
1977,
Pubmed
Vila,
DNA-induced alpha-helical structure in the NH2-terminal domain of histone H1.
2001,
Pubmed
Vyas,
N- and C-terminal domains determine differential nucleosomal binding geometry and affinity of linker histone isotypes H1(0) and H1c.
2012,
Pubmed
Whitlock,
Removal of histone H1 exposes a fifty base pair DNA segment between nucleosomes.
1976,
Pubmed
Woodcock,
Higher-order structure of chromatin and chromosomes.
2001,
Pubmed
Wu,
An intervening sequence in an unusual histone H1 gene of Tetrahymena thermophila.
1986,
Pubmed
Zhou,
Structural insights into the histone H1-nucleosome complex.
2013,
Pubmed
Zhou,
Position and orientation of the globular domain of linker histone H5 on the nucleosome.
1998,
Pubmed
Zhou,
Structural Mechanisms of Nucleosome Recognition by Linker Histones.
2015,
Pubmed
