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Neurotransmitter Switching Regulated by miRNAs Controls Changes in Social Preference.
Dulcis D
,
Lippi G
,
Stark CJ
,
Do LH
,
Berg DK
,
Spitzer NC
.
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Changes in social preference of amphibian larvae result from sustained exposure to kinship odorants. To understand the molecular and cellular mechanisms of this neuroplasticity, we investigated the effects of olfactory system activation on neurotransmitter (NT) expression in accessory olfactory bulb (AOB) interneurons during development. We show that protracted exposure to kin or non-kin odorants changes the number of dopamine (DA)- or gamma aminobutyric acid (GABA)-expressing neurons, with corresponding changes in attraction/aversion behavior. Changing the relative number of dopaminergic and GABAergic AOB interneurons or locally introducing DA or GABA receptor antagonists alters kinship preference. We then isolate AOB microRNAs (miRs) differentially regulated across these conditions. Inhibition of miR-375 and miR-200b reveals that they target Pax6 and Bcl11b to regulate the dopaminergic and GABAergic phenotypes. The results illuminate the role of NT switching governing experience-dependent social preference. VIDEO ABSTRACT.
Amin,
Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure.
2015, Pubmed
Amin,
Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure.
2015,
Pubmed
Aumann,
Differences in Number of Midbrain Dopamine Neurons Associated with Summer and Winter Photoperiods in Humans.
2016,
Pubmed
Aumann,
Environmental and behavioral modulation of the number of substantia nigra dopamine neurons in adult mice.
2013,
Pubmed
Bartel,
MicroRNAs: genomics, biogenesis, mechanism, and function.
2004,
Pubmed
Ben-Shaul,
In vivo vomeronasal stimulation reveals sensory encoding of conspecific and allospecific cues by the mouse accessory olfactory bulb.
2010,
Pubmed
Bhinge,
MiR-375 is Essential for Human Spinal Motor Neuron Development and May Be Involved in Motor Neuron Degeneration.
2016,
Pubmed
Borodinsky,
Activity-dependent homeostatic specification of transmitter expression in embryonic neurons.
2004,
Pubmed
,
Xenbase
Brill,
A dlx2- and pax6-dependent transcriptional code for periglomerular neuron specification in the adult olfactory bulb.
2008,
Pubmed
Cave,
Differential regulation of dopaminergic gene expression by Er81.
2010,
Pubmed
Chamero,
From genes to social communication: molecular sensing by the vomeronasal organ.
2012,
Pubmed
Chang,
MicroRNAs act sequentially and asymmetrically to control chemosensory laterality in the nematode.
2004,
Pubmed
Chen,
Mir-17-3p controls spinal neural progenitor patterning by regulating Olig2/Irx3 cross-repressive loop.
2011,
Pubmed
Choi,
Members of the miRNA-200 family regulate olfactory neurogenesis.
2008,
Pubmed
Davison,
Dopamine inhibits mitral/tufted--> granule cell synapses in the frog olfactory bulb.
2004,
Pubmed
de Chevigny,
miR-7a regulation of Pax6 controls spatial origin of forebrain dopaminergic neurons.
2012,
Pubmed
Demarque,
Activity-dependent expression of Lmx1b regulates specification of serotonergic neurons modulating swimming behavior.
2010,
Pubmed
,
Xenbase
Dulcis,
Neurotransmitter switching in the adult brain regulates behavior.
2013,
Pubmed
Dulcis,
Reserve pool neuron transmitter respecification: Novel neuroplasticity.
2012,
Pubmed
,
Xenbase
Dulcis,
Illumination controls differentiation of dopamine neurons regulating behaviour.
2008,
Pubmed
,
Xenbase
Ebert,
Roles for microRNAs in conferring robustness to biological processes.
2012,
Pubmed
Enomoto,
Bcl11b/Ctip2 controls the differentiation of vomeronasal sensory neurons in mice.
2011,
Pubmed
Friedländer,
Discovering microRNAs from deep sequencing data using miRDeep.
2008,
Pubmed
Gascon,
Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia.
2014,
Pubmed
Gerlach,
Kin recognition in zebrafish: a 24-hour window for olfactory imprinting.
2008,
Pubmed
Gessert,
FMR1/FXR1 and the miRNA pathway are required for eye and neural crest development.
2010,
Pubmed
,
Xenbase
Gu,
Distinct aspects of neuronal differentiation encoded by frequency of spontaneous Ca2+ transients.
1995,
Pubmed
,
Xenbase
Guemez-Gamboa,
Non-cell-autonomous mechanism of activity-dependent neurotransmitter switching.
2014,
Pubmed
,
Xenbase
Gutierrez,
Modulation of a Single Neuron Has State-Dependent Actions on Circuit Dynamics,
2014,
Pubmed
Gutiérrez,
Plasticity of the GABAergic phenotype of the "glutamatergic" granule cells of the rat dentate gyrus.
2003,
Pubmed
Hack,
Neuronal fate determinants of adult olfactory bulb neurogenesis.
2005,
Pubmed
Hagino-Yamagishi,
Expression of vomeronasal receptor genes in Xenopus laevis.
2004,
Pubmed
,
Xenbase
Harden,
Olfactory imprinting is correlated with changes in gene expression in the olfactory epithelia of the zebrafish.
2006,
Pubmed
Hino,
Molecular biological research on olfactory chemoreception in fishes.
2009,
Pubmed
Izaurralde,
GENE REGULATION. Breakers and blockers—miRNAs at work.
2015,
Pubmed
Janus,
Stability of preference for odors after short-term exposure in young spiny mice.
1993,
Pubmed
Johnstone,
Expression of olfactory receptors in different life stages and life histories of wild Atlantic salmon (Salmo salar).
2011,
Pubmed
Jungblut,
A putative functional vomeronasal system in anuran tadpoles.
2012,
Pubmed
Kaur,
Murine pheromone proteins constitute a context-dependent combinatorial code governing multiple social behaviors.
2014,
Pubmed
Kendrick,
Formation of olfactory memories mediated by nitric oxide.
1997,
Pubmed
Kendrick,
Neural control of maternal behaviour and olfactory recognition of offspring.
1997,
Pubmed
Kesby,
HIV-1 TAT protein enhances sensitization to methamphetamine by affecting dopaminergic function.
2017,
Pubmed
Kim,
A MicroRNA feedback circuit in midbrain dopamine neurons.
2007,
Pubmed
Kohwi,
Pax6 is required for making specific subpopulations of granule and periglomerular neurons in the olfactory bulb.
2005,
Pubmed
Kozomara,
miRBase: integrating microRNA annotation and deep-sequencing data.
2011,
Pubmed
Krol,
Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs.
2010,
Pubmed
Lewis,
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets.
2005,
Pubmed
Li,
Roles of small regulatory RNAs in determining neuronal identity.
2010,
Pubmed
Lippi,
Targeting of the Arpc3 actin nucleation factor by miR-29a/b regulates dendritic spine morphology.
2011,
Pubmed
Lippi,
MicroRNA-101 Regulates Multiple Developmental Programs to Constrain Excitation in Adult Neural Networks.
2016,
Pubmed
Livak,
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
2001,
Pubmed
Manning,
Communal nesting patterns in mice implicate MHC genes in kin recognition.
1992,
Pubmed
Marek,
cJun integrates calcium activity and tlx3 expression to regulate neurotransmitter specification.
2010,
Pubmed
,
Xenbase
McNeill,
MicroRNAs shape the neuronal landscape.
2012,
Pubmed
Menini,
Olfactory Coding in Larvae of the African Clawed Frog Xenopus laevis
2010,
Pubmed
Mezler,
Expression of olfactory receptors during development in Xenopus laevis.
1999,
Pubmed
,
Xenbase
Mullokandov,
High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries.
2012,
Pubmed
Ninkovic,
The transcription factor Pax6 regulates survival of dopaminergic olfactory bulb neurons via crystallin αA.
2010,
Pubmed
Porter,
Olfactory imprinting resulting from brief exposure in Acomys cahirinus.
1974,
Pubmed
Rungger-Brändle,
Retinal patterning by Pax6-dependent cell adhesion molecules.
2010,
Pubmed
,
Xenbase
Sansone,
Trpc2 is expressed in two olfactory subsystems, the main and the vomeronasal system of larval Xenopus laevis.
2014,
Pubmed
,
Xenbase
Scerbina,
Dopamine receptor antagonism disrupts social preference in zebrafish: a strain comparison study.
2012,
Pubmed
Shi,
miR-9 and miR-140-5p target FoxP2 and are regulated as a function of the social context of singing behavior in zebra finches.
2013,
Pubmed
Souza,
Dopamine D2 receptor activity modulates Akt signaling and alters GABAergic neuron development and motor behavior in zebrafish larvae.
2011,
Pubmed
Spitzer,
Neurotransmitter Switching in the Developing and Adult Brain.
2017,
Pubmed
Sturm,
Mouse urinary peptides provide a molecular basis for genotype discrimination by nasal sensory neurons.
2013,
Pubmed
Tan,
MicroRNA-128 governs neuronal excitability and motor behavior in mice.
2013,
Pubmed
Tang,
Genome-wide identification of Bcl11b gene targets reveals role in brain-derived neurotrophic factor signaling.
2011,
Pubmed
Tatton,
Rescue of dying neurons: a new action for deprenyl in MPTP parkinsonism.
1991,
Pubmed
Thiebes,
miR-218 is essential to establish motor neuron fate as a downstream effector of Isl1-Lhx3.
2015,
Pubmed
Velázquez-Ulloa,
Contexts for dopamine specification by calcium spike activity in the CNS.
2011,
Pubmed
,
Xenbase
Villinger,
Self-referent MHC type matching in frog tadpoles.
2008,
Pubmed
,
Xenbase
Visvanathan,
The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development.
2007,
Pubmed
Xu,
Derepression of a neuronal inhibitor due to miRNA dysregulation in a schizophrenia-related microdeletion.
2013,
Pubmed
Yamazaki,
Familial imprinting determines H-2 selective mating preferences.
1988,
Pubmed
Yoo,
MicroRNA-mediated switching of chromatin-remodelling complexes in neural development.
2009,
Pubmed
