Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Ecotoxicology
2018 Nov 01;279:1203-1216. doi: 10.1007/s10646-018-1972-y.
Show Gene links
Show Anatomy links
Linking organochlorine exposure to biomarker response patterns in Anurans: a case study of Müller's clawed frog (Xenopus muelleri) from a tropical malaria vector control region.
Wolmarans NJ
,
Du Preez LH
,
Yohannes YB
,
Ikenaka Y
,
Ishizuka M
,
Smit NJ
,
Wepener V
.
???displayArticle.abstract???
Organochlorine pesticides are highly persistent in aquatic ecosystems. Amphibians, specifically anurans, play an intricate part in the aquatic food web, and have very permeable skin which makes them prone to bioaccumulation of persistent pollutants. In this study the bioaccumulation of various legacy organochlorine pesticides (OCPs)-including dichlorodiphenyltrichloroethane (DDT), currently used for malaria vector control (MVC)-was assessed along with a set of biomarker responses in Müller's clawed frog Xenopus muelleri collected from the lower Phongolo River floodplain in South Africa. Possible relationships between bioaccumulation and biomarkers (of exposure, oxidative stress biomarkers, and cellular energy allocation) alongside their temporal changes were investigated. The OCP concentrations showed a significant increase over time for the duration of the study. The increase correlated negatively with rainfall from the region. DDT levels were well below expected effects levels with p,p-DDE being the main contributing metabolite. The results of this study indicate OCPs actively accumulate at sub-lethal levels in aquatic frogs from the study area, while showing possible relations towards some of the biochemical stress responses measured. Most notable were negative relationships indicated between p,p-DDE and acetylcholinesterase, malondialdehyde, and carbohydrates and protein energy availability. Levels of DDT were not found to be significantly higher than other legacy pesticides in the frog tissue, although evidence of newly introduced DDT in the frog tissue was found. Further investigation about sub-lethal effects of these pesticides on anurans is required to gain better insight into their full impact on animal livelihood.
Andersson,
Long-term effects of bleached kraft mill effluents on carbohydrate metabolism and hepatic xenobiotic biotransformation enzymes in fish.
1987, Pubmed
Andersson,
Long-term effects of bleached kraft mill effluents on carbohydrate metabolism and hepatic xenobiotic biotransformation enzymes in fish.
1987,
Pubmed
Banaee,
Biochemical and histological changes in the liver tissue of rainbow trout (Oncorhynchus mykiss) exposed to sub-lethal concentrations of diazinon.
2013,
Pubmed
Banerjee,
Biochemical effects of some pesticides on lipid peroxidation and free-radical scavengers.
1999,
Pubmed
BLIGH,
A rapid method of total lipid extraction and purification.
1959,
Pubmed
Borković-Mitić,
Biomarkers of oxidative stress and metal accumulation in marsh frog (Pelophylax ridibundus).
2016,
Pubmed
Bouwman,
DDT and malaria prevention: addressing the paradox.
2011,
Pubmed
Bradford,
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.
1976,
Pubmed
Buah-Kwofie,
The distribution of organochlorine pesticides in sediments from iSimangaliso Wetland Park: Ecological risks and implications for conservation in a biodiversity hotspot.
2017,
Pubmed
Carvalho,
Biomarker responses as indication of contaminant effects in Oreochromis niloticus.
2012,
Pubmed
Cohen,
Measurement of catalase activity in tissue extracts.
1970,
Pubmed
Cooke,
The influence of rearing density on the subsequent response to DDT dosing for tadpoles of the frog Rana temporaria.
1979,
Pubmed
De Coen,
The missing biomarker link: relationships between effects on the cellular energy allocation biomarker of toxicant-stressed Daphnia magna and corresponding population characteristics.
2003,
Pubmed
ELLMAN,
A new and rapid colorimetric determination of acetylcholinesterase activity.
1961,
Pubmed
Eriyamremu,
Alterations in glutathione reductase, superoxide dismutase, and lipid peroxidation of tadpoles (Xenopus laevis) exposed to Bonny Light crude oil and its fractions.
2008,
Pubmed
,
Xenbase
Falfushinska,
Different responses of biochemical markers in frogs (Rana ridibunda) from urban and rural wetlands to the effect of carbamate fungicide.
2008,
Pubmed
Gaspar,
Corrigendum to "Undisturbed dust as a metric of long-term indoor insecticide exposure: Residential DDT contamination from indoor residual spraying and its association with serum levels in the VHEMBE cohort" [Environ. Int. 85C (2015) 163-167].
2016,
Pubmed
Gerber,
Bioaccumulation and human health risk assessment of DDT and other organochlorine pesticides in an apex aquatic predator from a premier conservation area.
2016,
Pubmed
Gerber,
Biomarkers in tigerfish (Hydrocynus vittatus) as indicators of metal and organic pollution in ecologically sensitive subtropical rivers.
2018,
Pubmed
Jofré,
Organochlorine contamination in anuran amphibians of an artificial lake in the semiarid midwest of Argentina.
2008,
Pubmed
Kanter,
Acute effects of fenthion on certain oxidative stress biomarkers in various tissues of frogs (Rana ridibunda).
2012,
Pubmed
Kortenkamp,
Ten years of mixing cocktails: a review of combination effects of endocrine-disrupting chemicals.
2007,
Pubmed
La Merrill,
Toxicological function of adipose tissue: focus on persistent organic pollutants.
2013,
Pubmed
Melvin,
Altered bioenergetics and developmental effects in striped marsh frog (Limnodynastes peronii) tadpoles exposed to UV treated sewage.
2016,
Pubmed
Monastersky,
Biodiversity: Life--a status report.
2014,
Pubmed
Netherlands,
Biodiversity of frog haemoparasites from sub-tropical northern KwaZulu-Natal, South Africa.
2015,
Pubmed
Parvez,
Protein carbonyls: novel biomarkers of exposure to oxidative stress-inducing pesticides in freshwater fish Channa punctata (Bloch).
2005,
Pubmed
Prokić,
Antioxidative responses of the tissues of two wild populations of Pelophylax kl. esculentus frogs to heavy metal pollution.
2016,
Pubmed
Schoenaers,
Prioritization of contaminated watercourses using an integrated biomarker approach in caged carp.
2016,
Pubmed
Strandberg,
Concentration of organochlorine pesticides in wine corks.
2001,
Pubmed
Thompson,
Concentrations and human health risk assessment of DDT and its metabolites in free-range and commercial chicken products from KwaZulu-Natal, South Africa.
2017,
Pubmed
Uner,
Effects of diazinon on acetylcholinesterase activity and lipid peroxidation in the brain of Oreochromis niloticus.
2006,
Pubmed
van der Oost,
Fish bioaccumulation and biomarkers in environmental risk assessment: a review.
2003,
Pubmed
Van Dyk,
DDT contamination from indoor residual spraying for malaria control.
2010,
Pubmed
Verhaert,
Persistent organic pollutants in the Olifants River Basin, South Africa: Bioaccumulation and trophic transfer through a subtropical aquatic food web.
2017,
Pubmed
Verhaert,
Baseline levels and trophic transfer of persistent organic pollutants in sediments and biota from the Congo River Basin (DR Congo).
2013,
Pubmed
Verma,
Studies on the toxicity of lindane on Colisa fasciatus (part I: TLm measurements and histopathological changes in certain tissues).
1975,
Pubmed
Viljoen,
DDT exposure of frogs: A case study from Limpopo Province, South Africa.
2016,
Pubmed
,
Xenbase
Wepener,
Seasonal bioaccumulation of organohalogens in tigerfish, Hydrocynus vittatus Castelnau, from Lake Pongolapoort, South Africa.
2012,
Pubmed
Yohannes,
Assessment of DDT contamination in house rat as a possible bioindicator in DDT-sprayed areas from Ethiopia and South Africa.
2017,
Pubmed
Yohannes,
Organochlorine pesticides and heavy metals in fish from Lake Awassa, Ethiopia: Insights from stable isotope analysis.
2013,
Pubmed
