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J Cell Biol
1991 Dec 01;1156:1695-700. doi: 10.1083/jcb.115.6.1695.
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Localization of the DMDL gene-encoded dystrophin-related protein using a panel of nineteen monoclonal antibodies: presence at neuromuscular junctions, in the sarcolemma of dystrophic skeletal muscle, in vascular and other smooth muscles, and in proliferating brain cell lines.
Nguyen TM
,
Ellis JM
,
Love DR
,
Davies KE
,
Gatter KC
,
Dickson G
,
Morris GE
.
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mAbs have been raised against different epitopes on the protein product of the DMDL gene, which is an autosomal homologue of the X-linked DMD gene for dystrophin. These antibodies provide direct evidence that DMDL protein is localized near acetylcholine receptors at neuromuscular junctions in normal and mdx mouse intercostal muscle. The primary location in tissues other than skeletal muscle is smooth muscle, especially in the vascular system, which may account for the wide tissue distribution previously demonstrated by Western blotting. The DMDL protein was undetectable in the nonjunctional sarcolemma of normal human muscle, but was observed in nonjunctional sarcolemma of Duchenne muscular dystrophy patients, where dystrophin itself is absent or greatly reduced. The expression of DMDL protein is not restricted to smooth and skeletal muscle, however, since relatively large amounts are present in transformed brain cell lines of both glial and Schwann cell origin. This contrasts with the low levels of DMDL protein in adult braintissue.
Bar,
A novel product of the Duchenne muscular dystrophy gene which greatly differs from the known isoforms in its structure and tissue distribution.
1990, Pubmed
Bar,
A novel product of the Duchenne muscular dystrophy gene which greatly differs from the known isoforms in its structure and tissue distribution.
1990,
Pubmed
Buckle,
Localisation of a dystrophin-related autosomal gene to 6q24 in man, and to mouse chromosome 10 in the region of the dystrophia muscularis (dy) locus.
1990,
Pubmed
Fambrough,
Control of acetylcholine receptors in skeletal muscle.
1979,
Pubmed
Hoffman,
Detection of a specific isoform of alpha-actinin with antisera directed against dystrophin.
1989,
Pubmed
Hoffman,
Dystrophin: the protein product of the Duchenne muscular dystrophy locus.
1987,
Pubmed
Khurana,
Identification of a chromosome 6-encoded dystrophin-related protein.
1990,
Pubmed
Koenig,
Detailed analysis of the repeat domain of dystrophin reveals four potential hinge segments that may confer flexibility.
1990,
Pubmed
Koenig,
The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein.
1988,
Pubmed
Love,
Tissue distribution of the dystrophin-related gene product and expression in the mdx and dy mouse.
1991,
Pubmed
Love,
An autosomal transcript in skeletal muscle with homology to dystrophin.
1989,
Pubmed
Nguyen,
Monoclonal antibody evidence for structural similarities between the central rod regions of actinin and dystrophin.
1990,
Pubmed
Nguyen thi Man,
Monoclonal antibodies against defined regions of the muscular dystrophy protein, dystrophin.
1990,
Pubmed
Pons,
A homologue of dystrophin is expressed at the neuromuscular junctions of normal individuals and DMD patients, and of normal and mdx mice. Immunological evidence.
1991,
Pubmed
Sanes,
Expression of several adhesive macromolecules (N-CAM, L1, J1, NILE, uvomorulin, laminin, fibronectin, and a heparan sulfate proteoglycan) in embryonic, adult, and denervated adult skeletal muscle.
1986,
Pubmed
Tennekoon,
Transfection of neonatal rat Schwann cells with SV-40 large T antigen gene under control of the metallothionein promoter.
1987,
Pubmed
