Forman TE , Dennison BJC , Fantauzzo KA .

F31DE029364 NIDCR NIH HHS, R01DE027689 NIDCR NIH HHS, K02DE028572 NIDCR NIH HHS, F31 DE029364 NIDCR NIH HHS, R01 DE027689 NIDCR NIH HHS, K02 DE028572 NIDCR NIH HHS, T32 GM008497 NIGMS NIH HHS

             RNA binding
             neural crest cell fate determination

                X-linked monogenic disease
                myotonic dystrophy type 2
                specific developmental disorder
                pervasive developmental disorder
                macrocephaly-autism syndrome
                dystonia 16
                TARP syndrome
                microcephaly
                epilepsy
                Treacher Collins syndrome
                cleft palate
                cleft lip

           ROBIN SEQUENCE WITH CLEFT MANDIBLE AND LIMB ANOMALIES
           INTELLECTUAL DEVELOPMENTAL DISORDER, X-LINKED, SYNDROMIC, SHASHI TYPE; MRXSSH
           INTELLECTUAL DEVELOPMENTAL DISORDER, X-LINKED, SYNDROMIC, ARMFIELD TYPE; MRXSA
           FRAGILE X SYNDROME; FXS
           INTELLECTUAL DEVELOPMENTAL DISORDER, X-LINKED, SYNDROMIC, SNIJDERS BLOK TYPE; MRXSSB
           INTELLECTUAL DEVELOPMENTAL DISORDER, X-LINKED, SYNDROMIC, BAIN TYPE; MRXSB
           BASILICATA-AKHTAR SYNDROME; MRXSBA
           TARP SYNDROME; TARPS
           MYOTONIC DYSTROPHY 2; DM2
           DYSTONIA 16; DYT16
           AU-KLINE SYNDROME; AUKS
           DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 54; DEE54
           DEAFNESS, AUTOSOMAL RECESSIVE 109; DFNB109

Figure 1 RNA-binding proteins regulate RNA metabolism. The processes of transcription, splicing, nuclear export, trafficking, translation and decay are depicted. RNA-binding proteins (colored ovals) that regulate these processes and have a role in mammalian neural crest and/or craniofacial development are boxed in red. Pol II, RNA polymerase II; RBP, RNA-binding protein.

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