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While there is some evidence to suggest that disruption of the thyroid hormone (TH)-axis during perinatal development may weaken T cell immunity later in life, data are currently lacking on whether environmentally relevant thyroid disrupting chemicals (TDCs) can induce similar outcomes. To fill this gap in knowledge, X. laevis tadpoles were exposed to an environmentally relevant mixture of TDCs, either during early tadpole development, or immediately before and during metamorphosis, to assess T cell differentiation and anti-viral immune response against FV3 infection after metamorphosis. Extending our previous study showing a delay in metamorphosis completion, here we report that TDC exposure prior to metamorphosis reduced the frequency of surface MHC-II + splenic lymphocytes and weakened some aspects of the anti-viral immune response. TDC exposure during metamorphosis slowed post-metamorphic migration of the thymus reduced the renewal of cortical thymocytes and splenic CD8 + T cells. The results indicate that TDC exposure during perinatal development may perturb the formation of T cell immunity later in life.
Albornoz,
Gestational hypothyroidism increases the severity of experimental autoimmune encephalomyelitis in adult offspring.
2013, Pubmed
Albornoz,
Gestational hypothyroidism increases the severity of experimental autoimmune encephalomyelitis in adult offspring.
2013,
Pubmed
Barber,
GAPDH as a housekeeping gene: analysis of GAPDH mRNA expression in a panel of 72 human tissues.
2005,
Pubmed
Brunk,
Dissecting and modeling the emergent murine TEC compartment during ontogeny.
2017,
Pubmed
Bui-Marinos,
Prior induction of cellular antiviral pathways limits frog virus 3 replication in two permissive Xenopus laevis skin epithelial-like cell lines.
2021,
Pubmed
,
Xenbase
Carvalho,
Mixtures of chemical pollutants at European legislation safety concentrations: how safe are they?
2014,
Pubmed
Cowan,
Postnatal Involution and Counter-Involution of the Thymus.
2020,
Pubmed
De Jesús Andino,
Susceptibility of Xenopus laevis tadpoles to infection by the ranavirus Frog-Virus 3 correlates with a reduced and delayed innate immune response in comparison with adult frogs.
2012,
Pubmed
,
Xenbase
De Robertis,
A nose for the embryo: the work of Pieter Nieuwkoop.
1999,
Pubmed
Du Pasquier,
Expression of MHC class II antigens during Xenopus development.
1990,
Pubmed
,
Xenbase
Edholm,
Flow Cytometric Analysis of Xenopus Immune Cells.
2018,
Pubmed
,
Xenbase
Even-Desrumeaux,
Affinity determination of biotinylated antibodies by flow cytometry.
2012,
Pubmed
Fearon,
The expansion and maintenance of antigen-selected CD8(+) T cell clones.
2007,
Pubmed
Fini,
Parallel biotransformation of tetrabromobisphenol A in Xenopus laevis and mammals: Xenopus as a model for endocrine perturbation studies.
2012,
Pubmed
,
Xenbase
Gaimann,
Early life imprints the hierarchy of T cell clone sizes.
2020,
Pubmed
Gore,
EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals.
2015,
Pubmed
Gross,
Analysis of BTEX groundwater concentrations from surface spills associated with hydraulic fracturing operations.
2013,
Pubmed
Hackel,
TNF-α and IL-1β sensitize human MSC for IFN-γ signaling and enhance neutrophil recruitment.
2021,
Pubmed
Jordan,
THE BEHAVIOR OF THE LEUCOCYTES DURING COINCIDENT REGENERATION AND THYROID-INDUCED METAMORPHOSIS IN THE FROG LARVA, WITH A CONSIDERATION OF GROWTH FACTORS.
1924,
Pubmed
León Machado,
The MHC Class II Transactivator CIITA: Not (Quite) the Odd-One-Out Anymore among NLR Proteins.
2021,
Pubmed
Livak,
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
2001,
Pubmed
Marshall,
An introduction to immunology and immunopathology.
2018,
Pubmed
McGuire,
Thyroid Disrupting Chemicals in Mixture Perturb Thymocyte Differentiation in Xenopus laevis Tadpoles.
2021,
Pubmed
,
Xenbase
Mengeling,
A multi-tiered, in vivo, quantitative assay suite for environmental disruptors of thyroid hormone signaling.
2017,
Pubmed
,
Xenbase
Morales,
Innate immune responses and permissiveness to ranavirus infection of peritoneal leukocytes in the frog Xenopus laevis.
2010,
Pubmed
,
Xenbase
Morales,
Characterization of primary and memory CD8 T-cell responses against ranavirus (FV3) in Xenopus laevis.
2007,
Pubmed
,
Xenbase
Navarro,
Real-time PCR detection chemistry.
2015,
Pubmed
Plytycz,
Age-dependent changes in thymuses in the European common frog, Rana temporaria.
1995,
Pubmed
Robert,
Comparative and developmental study of the immune system in Xenopus.
2009,
Pubmed
,
Xenbase
Robert,
Xenopus as an experimental model for studying evolution of hsp--immune system interactions.
2004,
Pubmed
,
Xenbase
Robert,
Water Contaminants Associated With Unconventional Oil and Gas Extraction Cause Immunotoxicity to Amphibian Tadpoles.
2018,
Pubmed
,
Xenbase
Robert,
Developmental exposure to chemicals associated with unconventional oil and gas extraction alters immune homeostasis and viral immunity of the amphibian Xenopus.
2019,
Pubmed
,
Xenbase
Rollins-Smith,
Contribution of ventral blood island mesoderm to hematopoiesis in postmetamorphic and metamorphosis-inhibited Xenopus laevis.
1990,
Pubmed
,
Xenbase
Rollins-Smith,
Expression of class II major histocompatibility complex antigens on adult T cells in Xenopus is metamorphosis-dependent.
1990,
Pubmed
,
Xenbase
Rollins-Smith,
Thymus ontogeny in frogs: T-cell renewal at metamorphosis.
1992,
Pubmed
,
Xenbase
Rollins-Smith,
Effects of thyroid hormone deprivation on immunity in postmetamorphic frogs.
1993,
Pubmed
,
Xenbase
Thome,
Early-life compartmentalization of human T cell differentiation and regulatory function in mucosal and lymphoid tissues.
2016,
Pubmed
Turpen,
Induction and early development of the hematopoietic and immune systems in Xenopus.
1998,
Pubmed
,
Xenbase
Turpen,
Precursor immigration and thymocyte succession during larval development and metamorphosis in Xenopus.
1989,
Pubmed
,
Xenbase
Yang,
Dynamic Function and Composition Changes of Immune Cells During Normal and Pathological Pregnancy at the Maternal-Fetal Interface.
2019,
Pubmed
