Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Philos Trans R Soc Lond B Biol Sci
2023 Jul 31;3781882:20220124. doi: 10.1098/rstb.2022.0124.
Show Gene links
Show Anatomy links
A perspective into the relationships between amphibian (Xenopus laevis) myeloid cell subsets.
Hossainey MRH
,
Hauser KA
,
Garvey CN
,
Kalia N
,
Garvey JM
,
Grayfer L
.
???displayArticle.abstract??? Macrophage (Mϕ)-lineage cells are integral to the immune defences of all vertebrates, including amphibians. Across vertebrates, Mϕ differentiation and functionality depend on activation of the colony stimulating factor-1 (CSF1) receptor by CSF1 and interluekin-34 (IL34) cytokines. Our findings to date indicate that amphibian (Xenopus laevis) Mϕs differentiated with CSF1 and IL34 are morphologically, transcriptionally and functionally distinct. Notably, mammalian Mϕs share common progenitor population(s) with dendritic cells (DCs), which rely on fms-like tyrosine kinase 3 ligand (FLT3L) for differentiation while X. laevis IL34-Mϕs exhibit many features attributed to mammalian DCs. Presently, we compared X. laevis CSF1- and IL34-Mϕs with FLT3L-derived X. laevis DCs. Our transcriptional and functional analyses indicated that indeed the frog IL34-Mϕs and FLT3L-DCs possessed many commonalities over CSF1-Mϕs, including transcriptional profiles and functional capacities. Compared to X. laevis CSF1-Mϕs, the IL34-Mϕs and FLT3L-DCs possess greater surface major histocompatibility complex (MHC) class I, but not MHC class II expression, were better at eliciting mixed leucocyte responses in vitro and generating in vivo re-exposure immune responses against Mycobacterium marinum. Further analyses of non-mammalian myelopoiesis akin to those described here, will grant unique perspectives into the evolutionarily retained and diverged pathways of Mϕ and DC functional differentiation. This article is part of the theme issue 'Amphibian immunity: stress, disease and ecoimmunology'.
Aibar,
SCENIC: single-cell regulatory network inference and clustering.
2017, Pubmed
Aibar,
SCENIC: single-cell regulatory network inference and clustering.
2017,
Pubmed
Baud'huin,
Interleukin-34 is expressed by giant cell tumours of bone and plays a key role in RANKL-induced osteoclastogenesis.
2010,
Pubmed
Belosevic,
Development of goldfish macrophages in vitro.
2006,
Pubmed
Bonifer,
The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis.
2008,
Pubmed
Boulakirba,
IL-34 and CSF-1 display an equivalent macrophage differentiation ability but a different polarization potential.
2018,
Pubmed
Chihara,
IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation.
2010,
Pubmed
Chinchar,
Induction of apoptosis in frog virus 3-infected cells.
2003,
Pubmed
Ciau-Uitz,
Developmental hematopoiesis: ontogeny, genetic programming and conservation.
2014,
Pubmed
,
Xenbase
Cumano,
Ontogeny of the hematopoietic system.
2007,
Pubmed
De Kleer,
Ontogeny of myeloid cells.
2014,
Pubmed
Dress,
Monocytes and macrophages in severe COVID-19 - friend, foe or both?
2021,
Pubmed
Du Pasquier,
Expression of MHC class II antigens during Xenopus development.
1990,
Pubmed
,
Xenbase
Edholm,
Distinct MHC class I-like interacting invariant T cell lineage at the forefront of mycobacterial immunity uncovered in Xenopus.
2018,
Pubmed
,
Xenbase
Fitzgerald-Bocarsly,
Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history.
2008,
Pubmed
Flajnik,
MHC class I antigens as surface markers of adult erythrocytes during the metamorphosis of Xenopus.
1988,
Pubmed
,
Xenbase
Flajnik,
Major histocompatibility complex-encoded class I molecules are absent in immunologically competent Xenopus before metamorphosis.
1986,
Pubmed
,
Xenbase
Flajnik,
Evolution of the MHC: antigenicity and unusual tissue distribution of Xenopus (frog) class II molecules.
1990,
Pubmed
,
Xenbase
Grayfer,
Divergent antiviral roles of amphibian (Xenopus laevis) macrophages elicited by colony-stimulating factor-1 and interleukin-34.
2014,
Pubmed
,
Xenbase
Grayfer,
Distinct functional roles of amphibian (Xenopus laevis) colony-stimulating factor-1- and interleukin-34-derived macrophages.
2015,
Pubmed
,
Xenbase
Grayfer,
Prominent amphibian (Xenopus laevis) tadpole type III interferon response to the frog virus 3 ranavirus.
2015,
Pubmed
,
Xenbase
Grayfer,
Colony-stimulating factor-1-responsive macrophage precursors reside in the amphibian (Xenopus laevis) bone marrow rather than the hematopoietic subcapsular liver.
2013,
Pubmed
,
Xenbase
Grayfer,
Amphibian macrophage development and antiviral defenses.
2016,
Pubmed
,
Xenbase
Greer,
Five amphibian mortality events associated with ranavirus infection in south central Ontario, Canada.
2005,
Pubmed
Greter,
Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia.
2012,
Pubmed
Hauser,
Amphibian (Xenopus laevis) Tadpoles and Adult Frogs Differ in Their Antiviral Responses to Intestinal Frog Virus 3 Infections.
2021,
Pubmed
,
Xenbase
Herrero,
Immunosenescence of macrophages: reduced MHC class II gene expression.
2002,
Pubmed
Hettinger,
Origin of monocytes and macrophages in a committed progenitor.
2013,
Pubmed
Hossainey,
The Roles of Amphibian (Xenopus laevis) Macrophages during Chronic Frog Virus 3 Infections.
2021,
Pubmed
,
Xenbase
Hossainey,
A perspective into the relationships between amphibian (Xenopus laevis) myeloid cell subsets.
2023,
Pubmed
,
Xenbase
Jones,
Macrophages and CSF-1: implications for development and beyond.
2013,
Pubmed
Karsunky,
Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo.
2003,
Pubmed
Lan,
Trafficking of inflammatory macrophages from the kidney to draining lymph nodes during experimental glomerulonephritis.
1993,
Pubmed
Lin,
Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer.
2019,
Pubmed
Lin,
Discovery of a cytokine and its receptor by functional screening of the extracellular proteome.
2008,
Pubmed
Maraskovsky,
Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified.
1996,
Pubmed
Merad,
The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting.
2013,
Pubmed
Mildner,
Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis.
2013,
Pubmed
N'diaye,
Rat bone marrow-derived dendritic cells generated with GM-CSF/IL-4 or FLT3L exhibit distinct phenotypical and functional characteristics.
2016,
Pubmed
Naik,
Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes.
2006,
Pubmed
Neely,
"Double-duty" conventional dendritic cells in the amphibian Xenopus as the prototype for antigen presentation to B cells.
2018,
Pubmed
,
Xenbase
Orkin,
Hematopoiesis: an evolving paradigm for stem cell biology.
2008,
Pubmed
Paquin-Proulx,
Human interleukin-34-derived macrophages have increased resistance to HIV-1 infection.
2018,
Pubmed
Percivalle,
Macrophages and Monocytes: "Trojan Horses" in COVID-19.
2021,
Pubmed
Plantinga,
Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen.
2013,
Pubmed
Popovic,
Colony-stimulating factor-1- and interleukin-34-derived macrophages differ in their susceptibility to Mycobacterium marinum.
2019,
Pubmed
,
Xenbase
Ramsey,
Immune defenses against Batrachochytrium dendrobatidis, a fungus linked to global amphibian declines, in the South African clawed frog, Xenopus laevis.
2010,
Pubmed
,
Xenbase
Rhoo,
Distinct Host-Mycobacterial Pathogen Interactions between Resistant Adult and Tolerant Tadpole Life Stages of Xenopus laevis.
2019,
Pubmed
,
Xenbase
Robert,
Comparative and developmental study of the immune system in Xenopus.
2009,
Pubmed
,
Xenbase
Sato,
Contribution of dermal macrophage trafficking in the sensitization phase of contact hypersensitivity.
1998,
Pubmed
Schmid,
Instructive cytokine signals in dendritic cell lineage commitment.
2010,
Pubmed
Sichien,
Development of conventional dendritic cells: from common bone marrow progenitors to multiple subsets in peripheral tissues.
2017,
Pubmed
Wang,
Interkeukin-34, a cytokine crucial for the differentiation and maintenance of tissue resident macrophages and Langerhans cells.
2014,
Pubmed
Wendel,
Amphibian (Xenopus laevis) tadpoles and adult frogs mount distinct interferon responses to the Frog Virus 3 ranavirus.
2017,
Pubmed
,
Xenbase
Xaus,
The expression of MHC class II genes in macrophages is cell cycle dependent.
2000,
Pubmed
Yamane,
CSF-1 receptor-mediated differentiation of a new type of monocytic cell with B cell-stimulating activity: its selective dependence on IL-34.
2014,
Pubmed
Yaparla,
Myelopoiesis of the Amphibian Xenopus laevis Is Segregated to the Bone Marrow, Away From Their Hematopoietic Peripheral Liver.
2019,
Pubmed
,
Xenbase
Yaparla,
The unique myelopoiesis strategy of the amphibian Xenopus laevis.
2016,
Pubmed
,
Xenbase
Yaparla,
Exploring the relationships between amphibian (Xenopus laevis) myeloid cell subsets.
2020,
Pubmed
,
Xenbase
Yaparla,
Differentiation-dependent antiviral capacities of amphibian (Xenopus laevis) macrophages.
2018,
Pubmed
,
Xenbase
de Sousa,
Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases.
2019,
Pubmed
