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MicroPubl Biol
2023 Jan 01;2023. doi: 10.17912/micropub.biology.000919.
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Expression and cilia associated localization of Histone deacetylases 6 in Xenopus.
Tisler M
,
Ott T
,
Blum M
,
Schweickert A
.
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Histone deacetylases (HDACs) are key posttranslational modulators of the proteome. We show that expression of histone deacetylase 6 ( hdac6 ) is dynamic and appears in a tissue specific manner throughout embryonic development of the frog Xenopus laevis . Interestingly, hdac6 transcripts often associate with ciliated tissues, like the left-rightorganizer at neurula stage or the pronephros. In the embryonic skin, Hdac6 protein localizes to the cilia base, suggesting a functional link.
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