Pigment Cell Melanoma Res 2025 May 01;383:e70022. doi: 10.1111/pcmr.70022.

Cutaneous Pigment Cell Distributions and Skin Structure of Xenopus.

???displayArticle.abstract???
Pigment cells not only are intrinsic factors to determine animal patterns, but also play vital roles in numerous behavioral and physiological processes as well as health, such as melanomas originating from melanocytes. Model organisms are commonly used to study pigment cell development and the mechanisms underlying related diseases, with zebrafish and mice, and Xenopus being well-established examples. Xenopus tropicalis, a diploid amphibian model, offers advantages such as high fecundity and easily observable pigment cell development. Recent advancements in gene-editing techniques have increased its prominence in research on pigment cell biology and melanoma pathogenesis. Here, we compare the skin pigment cell distribution as well as the skin structure in X. tropicalis, zebrafish, mice, and humans and point out the potential value of using X. tropicalis to model human skin diseases, such as melanoma.

???displayArticle.pubmedLink??? 40329555
???displayArticle.link??? Pigment Cell Melanoma Res


Species referenced: Xenopus tropicalis Xenopus laevis
Genes referenced: adsl alk alx4 atic atp7a bco1 bco2 cdkn2b crip2 csf1r dct ednrb gart gbx2 gch1 gmps il2rg impdh1 ltk mitf mlana oca2 paics pax3 pax7 pfas pmel ppat prkdc prtfdc1 slc22a7 slc2a11 spr tfec tp53 tyr tyrp1 wnt1 xdh

???displayArticle.disOnts??? melanoma [+]
???displayArticle.omims??? MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 2; CMM2 [+]