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XB-ART-61690
Toxicon 2026 Jan 29;:109016. doi: 10.1016/j.toxicon.2026.109016.
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Identification and Functional Characterization of a Nav-Targeting Peptide NavTx-Bg1 from Sea Anemone Bunodosoma goanense (Vennam & den Hartog, 1993) Transcriptome.

Menezes C , Thakur N , Carleer K , Peigneur S , Tytgat J .


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Sea anemones are a rich source of venom peptides, many of which target voltage-gated sodium channels (Nav), having immense potential for therapeutic development. In this study, we employed a transcriptomics-guided approach to predict and functionally characterize a Nav-targeting peptide from the sea anemone Bunodosoma goanense. A single putative peptide transcript with homology to known sodium channel modulators was discovered. This transcript-derived peptide was chemically synthesized and tested for activity. Electrophysiological assays employing two-electrode voltage clamp (TEVC) on Xenopus laevis oocytes overexpressing Nav1.4 and Nav1.5 channels, along with contraction paralysis assay, confirmed its functional activity. Subsequent tentacle venom purification isolated a native peptide with the same bioactivity. Our work demonstrates the power of predictive transcriptomics for sustainable venom peptide discovery.

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