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Proc Natl Acad Sci U S A
2002 Nov 12;9923:14855-60. doi: 10.1073/pnas.222561499.
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Potentiation of serum response factor activity by a family of myocardin-related transcription factors.
Wang DZ
,
Li S
,
Hockemeyer D
,
Sutherland L
,
Wang Z
,
Schratt G
,
Richardson JA
,
Nordheim A
,
Olson EN
.
???displayArticle.abstract??? Myocardin is a SAP (SAF-A/B, Acinus, PIAS) domain transcription factor that associates with serum response factor (SRF) to potently enhance SRF-dependent transcription. Here we describe two myocardin-related transcription factors (MRTFs), A and B, that also interact with SRF and stimulate its transcriptional activity. Whereas myocardin is expressed specifically in cardiac and smooth muscle cells, MRTF-A and -B are expressed in numerous embryonic and adult tissues. In SRF-deficient embryonic stem cells, myocardin and MRTFs are unable to activate SRF-dependent reporter genes, confirming their dependence on SRF. Myocardin and MRTFs comprise a previously uncharacterized family of SRF cofactors with the potential to modulate SRF target genes in a wide range of tissues.
Aravind,
SAP - a putative DNA-binding motif involved in chromosomal organization.
2000, Pubmed
Aravind,
SAP - a putative DNA-binding motif involved in chromosomal organization.
2000,
Pubmed
Arsenian,
Serum response factor is essential for mesoderm formation during mouse embryogenesis.
1998,
Pubmed
Chang,
Muscle specificity encoded by specific serum response factor-binding sites.
2001,
Pubmed
Dalton,
Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element.
1992,
Pubmed
Escher,
Conservation of glutamine-rich transactivation function between yeast and humans.
2000,
Pubmed
Göhring,
The novel SAR-binding domain of scaffold attachment factor A (SAF-A) is a target in apoptotic nuclear breakdown.
1997,
Pubmed
Guan,
Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase.
1991,
Pubmed
Hill,
Functional analysis of a growth factor-responsive transcription factor complex.
1993,
Pubmed
Hill,
The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF.
1995,
Pubmed
Hipskind,
Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCF.
,
Pubmed
Hiroi,
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation.
2001,
Pubmed
,
Xenbase
Janknecht,
Activation of ternary complex factor Elk-1 by MAP kinases.
1993,
Pubmed
Kipp,
SAF-Box, a conserved protein domain that specifically recognizes scaffold attachment region DNA.
2000,
Pubmed
Li,
Evidence for serum response factor-mediated regulatory networks governing SM22alpha transcription in smooth, skeletal, and cardiac muscle cells.
1997,
Pubmed
Liu,
Inhibition of Stat1-mediated gene activation by PIAS1.
1998,
Pubmed
Ma,
Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia.
2001,
Pubmed
Mercher,
Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia.
2001,
Pubmed
Newberry,
The RRM domain of MINT, a novel Msx2 binding protein, recognizes and regulates the rat osteocalcin promoter.
1999,
Pubmed
Norman,
Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element.
1988,
Pubmed
Price,
Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET).
1995,
Pubmed
Rao,
elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints.
1989,
Pubmed
Sachdev,
PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies.
2001,
Pubmed
Sahara,
Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation.
1999,
Pubmed
Saluja,
Distinct subdomains of human TAFII130 are required for interactions with glutamine-rich transcriptional activators.
1998,
Pubmed
Schratt,
Serum response factor is required for immediate-early gene activation yet is dispensable for proliferation of embryonic stem cells.
2001,
Pubmed
Shin,
Modulation of cardiac growth and development by HOP, an unusual homeodomain protein.
2002,
Pubmed
,
Xenbase
Treisman,
Ternary complex factors: growth factor regulated transcriptional activators.
1994,
Pubmed
Wang,
Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor.
2001,
Pubmed
,
Xenbase
Weinhold,
Srf(-/-) ES cells display non-cell-autonomous impairment in mesodermal differentiation.
2000,
Pubmed
Wiellette,
spen encodes an RNP motif protein that interacts with Hox pathways to repress the development of head-like sclerites in the Drosophila trunk.
1999,
Pubmed
