Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
J Neurosci
2006 Jan 11;262:479-89. doi: 10.1523/JNEUROSCI.3915-05.2006.
Show Gene links
Show Anatomy links
Electrical hyperexcitation of lateralventral pacemaker neurons desynchronizes downstream circadian oscillators in the fly circadian circuit and induces multiple behavioral periods.
Nitabach MN
,
Wu Y
,
Sheeba V
,
Lemon WC
,
Strumbos J
,
Zelensky PK
,
White BH
,
Holmes TC
.
???displayArticle.abstract???
Coupling of autonomous cellular oscillators is an essential aspect of circadian clock function but little is known about its circuit requirements. Functional ablation of the pigment-dispersing factor-expressing lateralventral subset (LNV) of Drosophila clock neurons abolishes circadian rhythms of locomotor activity. The hypothesis that LNVs synchronize oscillations in downstream clock neurons was tested by rendering the LNVs hyperexcitable via transgenic expression of a low activation threshold voltage-gated sodium channel. When the LNVs are made hyperexcitable, free-running behavioral rhythms decompose into multiple independent superimposed oscillations and the clock protein oscillations in the dorsal neuron 1 and 2 subgroups of clock neurons are phase-shifted. Thus, regulated electrical activity of the LNVs synchronize multiple oscillators in the fly circadian pacemaker circuit.
Albus,
A GABAergic mechanism is necessary for coupling dissociable ventral and dorsal regional oscillators within the circadian clock.
2005, Pubmed
Albus,
A GABAergic mechanism is necessary for coupling dissociable ventral and dorsal regional oscillators within the circadian clock.
2005,
Pubmed
Baines,
Altered electrical properties in Drosophila neurons developing without synaptic transmission.
2001,
Pubmed
Blau,
Cycling vrille expression is required for a functional Drosophila clock.
1999,
Pubmed
Borodinsky,
Activity-dependent homeostatic specification of transmitter expression in embryonic neurons.
2004,
Pubmed
,
Xenbase
Brand,
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.
1993,
Pubmed
Brunner,
In vivo gene transfer of Kv1.5 normalizes action potential duration and shortens QT interval in mice with long QT phenotype.
2003,
Pubmed
Cyran,
vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock.
2003,
Pubmed
de la Iglesia,
Antiphase oscillation of the left and right suprachiasmatic nuclei.
2000,
Pubmed
de la Iglesia,
Forced desynchronization of dual circadian oscillators within the rat suprachiasmatic nucleus.
2004,
Pubmed
Ewer,
Control of insect ecdysis by a positive-feedback endocrine system: roles of eclosion hormone and ecdysis triggering hormone.
1997,
Pubmed
Grima,
Morning and evening peaks of activity rely on different clock neurons of the Drosophila brain.
2004,
Pubmed
Helfrich,
Role of the optic lobes in the regulation of the locomotor activity rhythm of Drosophila melanogaster: behavioral analysis of neural mutants.
1986,
Pubmed
Helfrich-Förster,
The circadian clock in the brain: a structural and functional comparison between mammals and insects.
2004,
Pubmed
Helfrich-Förster,
Ectopic expression of the neuropeptide pigment-dispersing factor alters behavioral rhythms in Drosophila melanogaster.
2000,
Pubmed
Helfrich-Förster,
The circadian clock of fruit flies is blind after elimination of all known photoreceptors.
2001,
Pubmed
Herzog,
Temporal precision in the mammalian circadian system: a reliable clock from less reliable neurons.
2004,
Pubmed
Hewes,
Voltage-dependent ionic currents in the ventromedial eclosion hormone neurons of Manduca sexta.
1999,
Pubmed
Jones,
Overexpression of a potassium channel gene perturbs neural differentiation.
1994,
Pubmed
,
Xenbase
Jones,
Overexpression of potassium channel RNA: in vivo development rescues neurons from suppression of morphological differentiation in vitro.
1995,
Pubmed
,
Xenbase
Kaneko,
Spatial and temporal expression of the period and timeless genes in the developing nervous system of Drosophila: newly identified pacemaker candidates and novel features of clock gene product cycling.
1997,
Pubmed
Kodirov,
Long-term restitution of 4-aminopyridine-sensitive currents in Kv1DN ventricular myocytes using adeno-associated virus-mediated delivery of Kv1.5.
2003,
Pubmed
Koilraj,
Presence of circadian rhythms in the locomotor activity of a cave-dwelling millipede Glyphiulus cavernicolus sulu (Cambalidae, Spirostreptida).
2000,
Pubmed
Lehmann-Horn,
Voltage-gated ion channels and hereditary disease.
1999,
Pubmed
Lima,
Remote control of behavior through genetically targeted photostimulation of neurons.
2005,
Pubmed
Lin,
The neuropeptide pigment-dispersing factor coordinates pacemaker interactions in the Drosophila circadian system.
2004,
Pubmed
Low-Zeddies,
Chimera analysis of the Clock mutation in mice shows that complex cellular integration determines circadian behavior.
2001,
Pubmed
Luan,
Functional dissection of a neuronal network required for cuticle tanning and wing expansion in Drosophila.
2006,
Pubmed
MacLean,
Activity-independent homeostasis in rhythmically active neurons.
2003,
Pubmed
,
Xenbase
Nagano,
An abrupt shift in the day/night cycle causes desynchrony in the mammalian circadian center.
2003,
Pubmed
Nitabach,
Membrane electrical excitability is necessary for the free-running larval Drosophila circadian clock.
2005,
Pubmed
Nitabach,
A mechanism for combinatorial regulation of electrical activity: Potassium channel subunits capable of functioning as Src homology 3-dependent adaptors.
2001,
Pubmed
,
Xenbase
Nitabach,
Electrical silencing of Drosophila pacemaker neurons stops the free-running circadian clock.
2002,
Pubmed
Park,
Differential regulation of circadian pacemaker output by separate clock genes in Drosophila.
2000,
Pubmed
Park,
Isolation and chronobiological analysis of a neuropeptide pigment-dispersing factor gene in Drosophila melanogaster.
1998,
Pubmed
Peng,
Drosophila free-running rhythms require intercellular communication.
2003,
Pubmed
Petri,
Pigment-dispersing hormone shifts the phase of the circadian pacemaker of the cockroach Leucophaea maderae.
1997,
Pubmed
Pradhan,
Meal scheduling modulation of circadian rhythm of phototactic behaviour in cave dwelling fish.
1989,
Pubmed
Price,
double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation.
1998,
Pubmed
Ren,
A prokaryotic voltage-gated sodium channel.
2001,
Pubmed
Renn,
A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila.
1999,
Pubmed
Schaap,
Heterogeneity of rhythmic suprachiasmatic nucleus neurons: Implications for circadian waveform and photoperiodic encoding.
2003,
Pubmed
Schneider,
Pigment-dispersing factor and GABA synchronize cells of the isolated circadian clock of the cockroach Leucophaea maderae.
2005,
Pubmed
Shafer,
Sequential nuclear accumulation of the clock proteins period and timeless in the pacemaker neurons of Drosophila melanogaster.
2002,
Pubmed
Stanewsky,
The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila.
1998,
Pubmed
Stewart,
Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions.
1994,
Pubmed
Stoleru,
Coupled oscillators control morning and evening locomotor behaviour of Drosophila.
2004,
Pubmed
Van Dongen,
A procedure of multiple period searching in unequally spaced time-series with the Lomb-Scargle method.
1999,
Pubmed
Veleri,
A self-sustaining, light-entrainable circadian oscillator in the Drosophila brain.
2003,
Pubmed
Welsh,
Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms.
1995,
Pubmed
White,
Targeted attenuation of electrical activity in Drosophila using a genetically modified K(+) channel.
2001,
Pubmed
Wicher,
Non-synaptic ion channels in insects--basic properties of currents and their modulation in neurons and skeletal muscles.
2001,
Pubmed
Yamaguchi,
Synchronization of cellular clocks in the suprachiasmatic nucleus.
2003,
Pubmed
Yang,
Role of molecular oscillations in generating behavioral rhythms in Drosophila.
2001,
Pubmed
Yang,
Response of the timeless protein to light correlates with behavioral entrainment and suggests a nonvisual pathway for circadian photoreception.
1998,
Pubmed
Yoshii,
Drosophila cryb mutation reveals two circadian clocks that drive locomotor rhythm and have different responsiveness to light.
2004,
Pubmed
