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Tanaka M
,
Schinke M
,
Liao HS
,
Yamasaki N
,
Izumo S
.
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Nkx2.5 and Nkx2.6 are murine homologs of Drosophila tinman. Their genes are expressed in the ventral region of the pharynx at early stages of embryogenesis. However, no abnormalities in the pharynges of embryos with mutations in either Nkx2.5 or Nkx2.6 have been reported. To examine the function of Nkx2.5 and Nkx2.6 in the formation of the pharynx, we generated and analyzed Nkx2.5 and Nkx2.6 double-mutant mice. Interestingly, in the double-mutant embryos, the pharynx did not form properly. Pharyngeal endodermal cells were largely missing, and the mutant pharynx was markedly dilated. Moreover, we observed enhanced apoptosis and reduced proliferation in pharyngeal endodermal cells of the double-mutant embryos. These results demonstrated a critical role of the NK-2 homeobox genes in the differentiation, proliferation, and survival of pharyngeal endodermal cells. Furthermore, the development of the atrium was less advanced in the double-mutant embryos, indicating that these two genes are essential for both pharyngeal and cardiac development.
Biben,
Expression of NK-2 class homeobox gene Nkx2-6 in foregut endoderm and heart.
1998, Pubmed
Biben,
Expression of NK-2 class homeobox gene Nkx2-6 in foregut endoderm and heart.
1998,
Pubmed
Bodmer,
The gene tinman is required for specification of the heart and visceral muscles in Drosophila.
1993,
Pubmed
Chiang,
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
1996,
Pubmed
Chisaka,
Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5.
1991,
Pubmed
Harvey,
NK-2 homeobox genes and heart development.
1996,
Pubmed
Komuro,
Csx: a murine homeobox-containing gene specifically expressed in the developing heart.
1993,
Pubmed
Lints,
Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants.
1993,
Pubmed
Litingtung,
Sonic hedgehog is essential to foregut development.
1998,
Pubmed
,
Xenbase
Lyons,
Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5.
1995,
Pubmed
Nascone,
An inductive role for the endoderm in Xenopus cardiogenesis.
1995,
Pubmed
,
Xenbase
Nikolova,
Nkx2.6 expression is transiently and specifically restricted to the branchial region of pharyngeal-stage mouse embryos.
1997,
Pubmed
Okkema,
The Caenorhabditis elegans NK-2 homeobox gene ceh-22 activates pharyngeal muscle gene expression in combination with pha-1 and is required for normal pharyngeal development.
1997,
Pubmed
Okkema,
The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscle.
1994,
Pubmed
Peters,
Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities.
1998,
Pubmed
Rudnicki,
MyoD or Myf-5 is required for the formation of skeletal muscle.
1993,
Pubmed
Schlaeger,
Vascular endothelial cell lineage-specific promoter in transgenic mice.
1995,
Pubmed
Schultheiss,
Induction of avian cardiac myogenesis by anterior endoderm.
1995,
Pubmed
,
Xenbase
Sugi,
Anterior endoderm is a specific effector of terminal cardiac myocyte differentiation of cells from the embryonic heart forming region.
1994,
Pubmed
Tanaka,
Vertebrate homologs of tinman and bagpipe: roles of the homeobox genes in cardiovascular development.
1998,
Pubmed
,
Xenbase
Tanaka,
Phenotypic characterization of the murine Nkx2.6 homeobox gene by gene targeting.
2000,
Pubmed
Tanaka,
The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development.
1999,
Pubmed
,
Xenbase
Weinstein,
The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo.
1994,
Pubmed
