XB-ART-9315
Cell Physiol Biochem
2001 Jan 01;111:55-60. doi: 10.1159/000047792.
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Determination of protein-protein interactions of ICIn by the yeast two-hybrid system.
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ICln is a ubiquitously expressed eukaryotic protein. Expression of the protein in Xenopus laevis oocytes, the knocking-down of the protein in fibroblasts, or the reconstitution of the protein in lipid bilayer led to the assumption that this protein is an ionic channel or a significant part thereof. However, other possible roles for ICln in potential regulatory mechanisms have been postulated, as diverse as regulator of cell morphology by interacting with the Skb1 protein and/or interaction with core spliceosomal proteins. Here we show that ICln is able to interact with SnRNP core proteins SmD1, SmD2, SmD3, SmX5 and SmB/B'.
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Species referenced: Xenopus laevis
Genes referenced: clns1a snrpd2