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XB-ART-9667
J Virol 2001 Mar 01;755:2314-23. doi: 10.1128/JVI.75.5.2314-2323.2001.
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Human GLI-2 is a tat activation response element-independent Tat cofactor.

Browning CM , Smith MJ , Clark NM , Lane BR , Parada C , Montano M , KewalRamani VN , Littman DR , Essex M , Roeder RG , Markovitz DM .


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Zinc finger-containing GLI proteins are involved in the development of Caenorhabditis elegans, Xenopus, Drosophila, zebrafish, mice, and humans. In this study, we show that an isoform of human GLI-2 strongly synergizes with the Tat transactivating proteins of human immunodeficiency virus types 1 and 2 (HIV-1 and -2) and markedly stimulates viral replication. GLI-2 also synergizes with the previously described Tat cofactor cyclin T1 to stimulate Tat function. Surprisingly, GLI-2/Tat synergy is not dependent on either a typical GLI DNA binding site or an intact Tat activation response element but does require an intact TATA box. Thus, GLI-2/Tat synergy results from a mechanism of action which is novel both for a GLI protein and for a Tat cofactor. These findings link the GLI family of transcriptional and developmental regulatory proteins to Tat function and HIV replication.

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References [+] :
Alexandre, Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. 1996, Pubmed