Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
RNA
2000 Nov 01;611:1635-48. doi: 10.1017/s1355838200000819.
Show Gene links
Show Anatomy links
Dual role for the RNA-binding domain of Xenopus laevis SLBP1 in histone pre-mRNA processing.
Ingledue TC
,
Dominski Z
,
Sánchez R
,
Erkmann JA
,
Marzluff WF
.
???displayArticle.abstract???
The replication-dependent histone mRNAs end in a conserved 26-nt sequence that forms a stem-loop structure. This sequence is required for histone pre-mRNA processing and plays a role in multiple aspects of histone mRNA metabolism. Two proteins that bind the 3' end of histone mRNA are found in Xenopus oocytes. xSLBP1 is found in the nucleus, where it functions in histone pre-mRNA processing, and in the cytoplasm, where it may control histone mRNA translation and stability. xSLBP2 is a cytoplasmic protein, inactive in histone pre-mRNA processing, whose expression is restricted to oogenesis and early development. These proteins are similar only in their RNA-binding domains (RBD). A chimeric protein (1-2-1) in which the RBD of xSLBP1 has been replaced with the RBD of xSLBP2 binds the stem-loop with an affinity similar to the original protein. The 1-2-1 protein efficiently localizes to the nucleus of the frog oocyte, but is not active in processing of histone pre-mRNA in vivo. This protein does not support processing in a nuclear extract, but inhibits processing by competing with the active SLBP by binding to the substrate. The 1-2-1 protein also inhibits processing of synthetic histone pre-mRNA injected into frog oocytes, but has no effect on processing of histone pre-mRNA transcribed from an injected histone gene. This result suggests that sequences in the RBD of xSLBP1 give it preferential access to histone pre-mRNA transcribed in vivo.
Abbott,
The stem-loop binding protein (SLBP1) is present in coiled bodies of the Xenopus germinal vesicle.
1999, Pubmed,
Xenbase
Abbott,
The stem-loop binding protein (SLBP1) is present in coiled bodies of the Xenopus germinal vesicle.
1999,
Pubmed
,
Xenbase
Bellini,
Coilin can form a complex with the U7 small nuclear ribonucleoprotein.
1998,
Pubmed
,
Xenbase
Bentley,
Accurate, TATA box-dependent polymerase III transcription from promoters of the c-myc gene in injected Xenopus oocytes.
1989,
Pubmed
,
Xenbase
Bentley,
Sequence requirements for premature termination of transcription in the human c-myc gene.
1988,
Pubmed
,
Xenbase
Callan,
Histone genes are located at the sphere loci of Xenopus lampbrush chromosomes.
1991,
Pubmed
,
Xenbase
Cho,
Decreasing the distance between the two conserved sequence elements of histone pre-messenger RNA interferes with 3' processing in vitro.
1995,
Pubmed
Cotten,
Specific contacts between mammalian U7 snRNA and histone precursor RNA are indispensable for the in vitro 3' RNA processing reaction.
1988,
Pubmed
Dominski,
The polyribosomal protein bound to the 3' end of histone mRNA can function in histone pre-mRNA processing.
1995,
Pubmed
Dominski,
Stem-loop binding protein facilitates 3'-end formation by stabilizing U7 snRNP binding to histone pre-mRNA.
1999,
Pubmed
Dominski,
Formation of the 3' end of histone mRNA.
1999,
Pubmed
Eckner,
Mature mRNA 3' end formation stimulates RNA export from the nucleus.
1991,
Pubmed
Frey,
Coiled bodies contain U7 small nuclear RNA and associate with specific DNA sequences in interphase human cells.
1995,
Pubmed
Gallie,
The histone 3'-terminal stem-loop is necessary for translation in Chinese hamster ovary cells.
1996,
Pubmed
Gick,
Generation of histone mRNA 3' ends by endonucleolytic cleavage of the pre-mRNA in a snRNP-dependent in vitro reaction.
1986,
Pubmed
Gick,
Heat-labile regulatory factor is required for 3' processing of histone precursor mRNAs.
1987,
Pubmed
Hanson,
Efficient extraction and partial purification of the polyribosome-associated stem-loop binding protein bound to the 3' end of histone mRNA.
1996,
Pubmed
Jacobs,
Coiled bodies preferentially associate with U4, U11, and U12 small nuclear RNA genes in interphase HeLa cells but not with U6 and U7 genes.
1999,
Pubmed
Kay,
Xenopus laevis: Practical uses in cell and molecular biology. Injections of oocytes and embryos.
1991,
Pubmed
,
Xenbase
Krieg,
Formation of the 3' end of histone mRNA by post-transcriptional processing.
,
Pubmed
,
Xenbase
Longo,
Changes in nuclear localization of An3, a RNA helicase, during oogenesis and embryogenesis in Xenopus laevis.
1996,
Pubmed
,
Xenbase
Martin,
The gene for histone RNA hairpin binding protein is located on human chromosome 4 and encodes a novel type of RNA binding protein.
1997,
Pubmed
Marzluff,
Histone 3' ends: essential and regulatory functions.
1992,
Pubmed
Matera,
Nuclear bodies: multifaceted subdomains of the interchromatin space.
1999,
Pubmed
Matsumoto,
Nuclear history of a pre-mRNA determines the translational activity of cytoplasmic mRNA.
1998,
Pubmed
,
Xenbase
McCracken,
The C-terminal domain of RNA polymerase II couples mRNA processing to transcription.
1997,
Pubmed
Melin,
Biochemical demonstration of complex formation of histone pre-mRNA with U7 small nuclear ribonucleoprotein and hairpin binding factors.
1992,
Pubmed
Meric,
Masking and unmasking maternal mRNA. The role of polyadenylation, transcription, splicing, and nuclear history.
1996,
Pubmed
,
Xenbase
Mowry,
Identification of the human U7 snRNP as one of several factors involved in the 3' end maturation of histone premessenger RNA's.
1987,
Pubmed
Pandey,
Point mutations in the stem-loop at the 3' end of mouse histone mRNA reduce expression by reducing the efficiency of 3' end formation.
1994,
Pubmed
Pandey,
The stem-loop structure at the 3' end of histone mRNA is necessary and sufficient for regulation of histone mRNA stability.
1987,
Pubmed
Scharl,
Length suppression in histone messenger RNA 3'-end maturation: processing defects of insertion mutant premessenger RNAs can be compensated by insertions into the U7 small nuclear RNA.
1996,
Pubmed
,
Xenbase
Scharl,
The site of 3' end formation of histone messenger RNA is a fixed distance from the downstream element recognized by the U7 snRNP.
1994,
Pubmed
Soldati,
Structural and functional characterization of mouse U7 small nuclear RNA active in 3' processing of histone pre-mRNA.
1988,
Pubmed
Spycher,
3' end processing of mouse histone pre-mRNA: evidence for additional base-pairing between U7 snRNA and pre-mRNA.
1994,
Pubmed
,
Xenbase
Stauber,
3' processing of pre-mRNA plays a major role in proliferation-dependent regulation of histone gene expression.
1988,
Pubmed
Stefanovic,
A synthetic histone pre-mRNA-U7 small nuclear RNA chimera undergoing cis cleavage in the cytoplasm of Xenopus oocytes.
1995,
Pubmed
,
Xenbase
Streit,
Variable effects of the conserved RNA hairpin element upon 3' end processing of histone pre-mRNA in vitro.
1993,
Pubmed
Strub,
Genetic complementation in the Xenopus oocyte: co-expression of sea urchin histone and U7 RNAs restores 3' processing of H3 pre-mRNA in the oocyte.
1986,
Pubmed
,
Xenbase
Sun,
The histone mRNA 3' end is required for localization of histone mRNA to polyribosomes.
1992,
Pubmed
Wang,
Characterization of the mouse histone gene cluster on chromosome 13: 45 histone genes in three patches spread over 1Mb.
1996,
Pubmed
Wang,
Characterization of the 55-kb mouse histone gene cluster on chromosome 3.
1996,
Pubmed
Wang,
The protein that binds the 3' end of histone mRNA: a novel RNA-binding protein required for histone pre-mRNA processing.
1996,
Pubmed
Wang,
Two Xenopus proteins that bind the 3' end of histone mRNA: implications for translational control of histone synthesis during oogenesis.
1999,
Pubmed
,
Xenbase
Williams,
Changes in the stem-loop at the 3' terminus of histone mRNA affects its nucleocytoplasmic transport and cytoplasmic regulation.
1994,
Pubmed
,
Xenbase
Williams,
The sequence of the stem and flanking sequences at the 3' end of histone mRNA are critical determinants for the binding of the stem-loop binding protein.
1995,
Pubmed
Wu,
The Sm binding site targets U7 snRNA to coiled bodies (spheres) of amphibian oocytes.
1996,
Pubmed
,
Xenbase
Wu,
U7 small nuclear RNA in C snurposomes of the Xenopus germinal vesicle.
1993,
Pubmed
,
Xenbase
