Mitcheson JS , Chen J , Lin M , Culberson C , Sanguinetti MC .

HL55236 NHLBI NIH HHS , R01 HL055236 NHLBI NIH HHS

Abbott, MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. 1999, Pubmed, Xenbase

Abbott, MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. 1999, Pubmed , Xenbase
Crumb, QT interval prolongation by non-cardiovascular drugs: issues and solutions for novel drug development. 1999, Pubmed
Curran, A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. 1995, Pubmed
Doyle, The structure of the potassium channel: molecular basis of K+ conduction and selectivity. 1998, Pubmed
Ficker, Molecular determinants of dofetilide block of HERG K+ channels. 1998, Pubmed , Xenbase
Goldin, Expression of ion channels by injection of mRNA into Xenopus oocytes. 1992, Pubmed , Xenbase
Goldin, Preparation of RNA for injection into Xenopus oocytes. 1992, Pubmed , Xenbase
Hockerman, Molecular determinants of high affinity phenylalkylamine block of L-type calcium channels in transmembrane segment IIIS6 and the pore region of the alpha1 subunit. 1997, Pubmed
Hockerman, Molecular determinants of high affinity phenylalkylamine block of L-type calcium channels. 1995, Pubmed
Kass, Channel structure and drug-induced cardiac arrhythmias. 2000, Pubmed
Keating, Molecular genetic insights into cardiovascular disease. 1996, Pubmed
Lees-Miller, Molecular determinant of high-affinity dofetilide binding to HERG1 expressed in Xenopus oocytes: involvement of S6 sites. 2000, Pubmed , Xenbase
Lynch, Cardiac electrophysiologic and antiarrhythmic actions of two long-acting spirobenzopyran piperidine class III agents, L-702,958 and L-706,000 [MK-499]. 1994, Pubmed
Miller, FLOG: a system to select 'quasi-flexible' ligands complementary to a receptor of known three-dimensional structure. 1994, Pubmed
Mitcheson, Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate. 2000, Pubmed , Xenbase
Mohammad, Blockage of the HERG human cardiac K+ channel by the gastrointestinal prokinetic agent cisapride. 1997, Pubmed
Peterson, Analysis of the dihydropyridine receptor site of L-type calcium channels by alanine-scanning mutagenesis. 1997, Pubmed
Ragsdale, Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels. 1996, Pubmed
Roden, Multiple mechanisms in the long-QT syndrome. Current knowledge, gaps, and future directions. The SADS Foundation Task Force on LQTS. 1996, Pubmed
Roden, Mechanisms and management of proarrhythmia. 1998, Pubmed
Roy, HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine. 1996, Pubmed , Xenbase
Sanguinetti, A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. 1995, Pubmed , Xenbase
Sanguinetti, Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes. 1999, Pubmed , Xenbase
Smith, The inward rectification mechanism of the HERG cardiac potassium channel. 1996, Pubmed
Spector, Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides. 1996, Pubmed , Xenbase
Stühmer, Electrophysiological recording from Xenopus oocytes. 1992, Pubmed , Xenbase
Trudeau, HERG, a human inward rectifier in the voltage-gated potassium channel family. 1995, Pubmed
Wang, Modulation of HERG affinity for E-4031 by [K+]o and C-type inactivation. 1998, Pubmed , Xenbase
Wang, Time, voltage and ionic concentration dependence of rectification of h-erg expressed in Xenopus oocytes. 1996, Pubmed , Xenbase
Warmke, A family of potassium channel genes related to eag in Drosophila and mammals. 1994, Pubmed
Zou, Single HERG delayed rectifier K+ channels expressed in Xenopus oocytes. 1997, Pubmed , Xenbase
del Camino, Blocker protection in the pore of a voltage-gated K+ channel and its structural implications. 2000, Pubmed