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Development 2000 Jul 01;12713:2773-84. doi: 10.1242/dev.127.13.2773.
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RGS proteins inhibit Xwnt-8 signaling in Xenopus embryonic development.

Wu C , Zeng Q , Blumer KJ , Muslin AJ .

RGS family members are GTPase activating proteins (GAPs) that antagonize signaling by heterotrimeric G proteins. Injection of Xenopus embryos with RNA encoding rat RGS4 (rRGS4), a GAP for G(i) and G(q), resulted in shortened trunks and decreased skeletal muscle. This phenotype is nearly identical to the effect of injection of either frzb or dominant negative Xwnt-8. Injection of human RGS2, which selectively deactivates G(q), had similar effects. rRGS4 inhibited the ability of early Xwnt-8 but not Xdsh misexpression to cause axis duplication. This effect is distinct from axin family members that contain RGS-like domains but act downstream of Xdsh. We identified two Xenopus RGS4 homologs, one of which, Xrgs4a, was expressed as a Spemann organizer component. Injection of Xenopus embryos with Xrgs4a also resulted in shortened trunks and decreased skeletal muscle. These results suggest that RGS proteins modulate Xwnt-8 signaling by attenuating the function of a G protein.

PubMed ID: 10851124
Article link: Development

Species referenced: Xenopus
Genes referenced: dvl1 frzb gnaq myod1 odc1 rgs2 rgs4 tbxt wnt8a

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