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Science 2000 Jun 09;2885472:1825-8.
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Signaling specificity by Frizzled receptors in Drosophila.

Boutros M , Mihaly J , Bouwmeester T , Mlodzik M .

Wnt-Frizzled (Fz) signaling pathways play recurring important roles during the development and homeostasis of vertebrates and invertebrates. Fz receptors can signal through beta-catenin-dependent and -independent pathways. In Drosophila, Fz and Fz2 are redundant receptors for Wg. In addition, Fz conveys signals through a distinct pathway to organize planar polarization of epithelial structures. We demonstrate that the cytoplasmic sequences of Fz2 and Fz preferentially activate the beta-catenin and planar polarity cascade, respectively. Both receptors activate either pathway, but with different efficiencies. Intrinsic differences in signaling efficiency in closely related receptors might be a general mechanism for generating signaling specificity in vivo.

PubMed ID: 10846164
Article link: Science

Species referenced: Xenopus
Genes referenced: fzd2