XB-ART-11318Mech Dev 2000 Apr 01;922:291-4. doi: 10.1016/s0925-4773(99)00345-7.
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Expression of CRYP-alpha, LAR, PTP-delta, and PTP-rho in the developing Xenopus visual system.
Receptor protein tyrosine phosphatases (RPTPs), are involved in axon outgrowth and guidance not only in the Drosophila visual system (Garrity et al., 1999. Neuron 22, 707-717) but also in the developing vertebrate retina (Ledig et al., 1999a. J. Cell Biol. 147, 375-388). We have cloned a variety of Xenopus RPTPs, including four RPTPs expressed in the developing visual system (LAR, PTP-delta, CRYP-alpha and PTP-rho). These four RPTPs are transcribed in the developing optic vesicle during differentiation and in overlapping but distinct patterns in the developing retina during retinal layer formation. LAR, PTP-delta, and CRYP-alpha are also expressed in retinal ganglion cells during axonogenesis and during axon guidance from the retina to the optic tectum.
PubMed ID: 10727868
Article link: Mech Dev
Species referenced: Xenopus
Genes referenced: ptprd ptprf ptprs ptprt ptpru rho tbx2 tgm2
Article Images: [+] show captions
|Fig. 2. Whole-mount in situ hybridizations using antisense DIG-labeled mRNA probes for CRYP-α, LAR, PTP-δ, and PTP-ρ in the developing albino Xenopus embryo at stages 19 (A,D,G,J); 24 (E,H)–25 (B,K); and stages 28 (C,F,L)–29/30 (I). For the stage-19 embryos, anterior is up (dorsal view). For all other embryos, anterior is right and dorsal is up. OV, optic vesicle; LPM, lateral plate mesoderm; S, somite; TGC, trigeminal complex; N, notochord; SC, spinal cord; Hb, hindbrain; Mb, midbrain; Fb, forebrain; NT, neural tube.|
|Fig. 3. In situ hybridizations using antisense DIG-labeled mRNA probes for CRYP-α, LAR, PTP-δ, and PTP-ρ on 15-μm paraffin-sectioned pigmented Xenopus retinae at stages 35/36, 39 and 41. Sections are near the retinal midline, and dorsal is up. GCL, ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer.|
|ptprs (protein tyrosine phosphatase receptor type S) gene expression in X. laevis, NF stage 28,asayed via in situ hybridization, lateral view, anterior right, dorsal up. Key: N=notochord; SC= spinal cord; Hb= hindbrain; Mb= midbrain; Fb= forebrain; TGc= trigeminal ganglion; S= somites., Eye=eye.|