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FEBS Lett 1999 Sep 24;4583:295-8.
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Activation of channel activity of the NMDA receptor-PSD-95 complex by guanylate kinase-associated protein (GKAP).

Yamada Y , Chochi Y , Ko JA , Sobue K , Inui M .

The channel-associated protein PSD-95 functionally modulates NMDA receptor channels, interacting with the channels via PDZ domain of PSD-95. PSD-95 also interacts with guanylate kinase-associated protein (GKAP) through the guanylate kinase-like domain of PSD-95. Here we report that GKAP markedly potentiates the channel activity of the receptor-PSD-95 complex. However, GKAP had no effect on basic properties of the channels nor on PSD-95-induced changes in channel properties. Thus, GKAP affects the channel activity of the NMDA receptor via PSD-95 quantitatively, which may make signal transmission more efficient at postsynaptic sites.

PubMed ID: 10570927
Article link: FEBS Lett

Species referenced: Xenopus laevis
Genes referenced: dlg4 dlgap1 guk1 psd