Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-11919
Nat Neurosci 1999 Dec 01;212:1084-90. doi: 10.1038/16012.
Show Gene links Show Anatomy links

G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action.

Lewohl JM , Wilson WR , Mayfield RD , Brozowski SJ , Morrisett RA , Harris RA .


Abstract
G-protein-coupled inwardly rectifying potassium channels (GIRKs) are important for regulation of synaptic transmission and neuronal firing rates. Because of their key role in brain function, we asked if these potassium channels are targets of alcohol action. Ethanol enhanced function of cerebellar granule cell GIRKs coupled to GABAB receptors. Enhancement of GIRK function by ethanol was studied in detail using Xenopus oocytes expressing homomeric or heteromeric channels. Function of all GIRK channels was enhanced by intoxicating concentrations of ethanol, but other, related inwardly rectifying potassium channels were not affected. GIRK2/IRK1 chimeras and GIRK2 truncation mutants were used to identify a region of 43 amino acids in the carboxyl (C) terminus that is critical for the action of ethanol on these channels.

PubMed ID: 10570485
Article link: Nat Neurosci
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: kcnj12 kcnj2 kcnj3 kcnj6