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Mech Dev 1999 Jan 01;801:3-13.
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A Meis family protein caudalizes neural cell fates in Xenopus.

Salzberg A , Elias S , Nachaliel N , Bonstein L , Henig C , Frank D .

A homologue of the Drosophila homothorax (hth) gene, Xenopus Meis3 (XMeis3), was cloned from Xenopus laevis. XMeis3 is expressed in a single stripe of cells in the early neural plate stage. By late neurula, the gene is expressed predominantly in rhombomeres two, three and four, and in the anterior spinal cord. Ectopic expression of RNA encoding XMeis3 protein causes anterior neural truncations with a concomitant expansion of hindbrain and spinal cord. Ectopic XMeis3 expression inhibits anterior neural induction in neuralized animal cap ectoderm explants without perturbing induction of pan-neural markers. In naive animal cap ectoderm, ectopic XMeis3 expression activates transcription of the posteriorly expressed neural markers, but not pan-neural markers. These results suggest that caudalizing proteins, such as XMeis3, can alter A-P patterning in the nervous system in the absence of neural induction. Regionally expressed proteins like XMeis3 could be required to overcome anterior signals and to specify posterior cell fates along the A-P axis.

PubMed ID: 10096059
Article link: Mech Dev

Species referenced: Xenopus laevis
Genes referenced: ag1 eef1a2 egr2 en2 epha2 hoxb9 hoxd1 meis1 meis2 meis3 nog nrp1 otx2 pax3 rara zic1
Morpholinos: meis3 MO1 pax3 MO4 zic1 MO1

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