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Development 1996 Mar 01;1223:1007-15.
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TGF-beta signals and a pattern in Xenopus laevis endodermal development.

Henry GL , Brivanlou IH , Kessler DS , Hemmati-Brivanlou A , Melton DA .

We have analyzed two gene products expressed in the early endoderm of Xenopus laevis: Xlhbox-8, a pancreas-specific transcription factor and intestinal fatty acid binding protein (IFABP), a marker of small intestinal epithelium. Expression of the pancreas marker relies on cell signaling mediated by both the TGF-beta and FGF classes of secreted peptide growth factors, whereas, expression of the more posterior small intestinal marker does not. Endodermal explants devoid of mesoderm express both markers in a regionalized manner. Cortical rotation is required for the expression of the more anterior marker, Xlhbox-8, but not for the small intestinal marker, IFABP. These findings suggest that endodermal patterning is dependent, in part, on the same events and signals known to play important roles in mesodermal development. Furthermore, inhibition of TGF-beta signaling in the endoderm leads to ectopic expression of both mesodermal and ectodermal markers, suggesting the TGF-beta signaling may play a general role in the segregation of the three embryonic germ layers.

PubMed ID: 8631246

Species referenced: Xenopus laevis
Genes referenced: actl6a fabp2 fst gdf1 hba3 ins krt12.4 ncam1 pdx1 tbxt twist1
Antibodies: Gut Ab1 Pdx1 Ab1

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