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Dev Biol 1995 Nov 01;1721:337-42. doi: 10.1006/dbio.1995.0027.
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Specification of the anteroposterior neural axis through synergistic interaction of the Wnt signaling cascade with noggin and follistatin.

McGrew LL , Lai CJ , Moon RT .

Embryological data and the activities of the neural-inducing factors noggin and follistatin are consistent with the hypothesis that the nervous system is initially induced with an anterior character, with subsequent signals imparting posterior pattern. We report that Xwnt3a is a candidate for involvement in anteroposterior neural patterning, as it synergizes with the neural-inducing factors noggin and follistatin to increase the expression of posterior neural genes. Furthermore we show that beta-catenin, an intracellular protein implicated in the Wnt signal transduction cascade, mimics the activity of Xwnt3a. These data suggest that the generation of pattern within the vertebrate nervous system may rely on synergism between a Wnt signaling pathway and multiple neural-inducing factors.

PubMed ID: 7589812
Article link: Dev Biol
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: ag1 fst hesx1 ihh ncam1 nog nrp1 otx2 prl.1 shh wnt3a

Article Images: [+] show captions