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XB-ART-19387
Int J Dev Biol 1995 Aug 01;394:597-603.
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Developmentally regulated chromatin acetylation and histone H1(0) accumulation.

Seigneurin D , Grunwald D , Lawrence JJ , Khochbin S .


Abstract
There exists a close relationship between core histone acetylation and the induced expression of the histone H1(0) gene. We took advantage of this fact to evaluate the influence of chromatin hyperacetylation on the developmentally regulated expression of this specific gene. In this study, the in situ immunodetection approach has been used to analyze both the acetylated histone H4 isoforms and histone H1(0) accumulation during early Xenopus laevis development. We have chosen two stages of development, gastrula stage, when H1(0) is not expressed and not inducible by butyrate treatment, and stage 27 when H1(0) is not expressed but is inducible by butyrate. At stage 27 of development, the early induced accumulation of histone H1(0) under butyrate treatment, occurs mainly in tissues that express the protein normally during later development. These experiments suggest that histone acetylation may be part of a pathway which, in a specific set of cells, keeps H1(0) and probably a series of specific genes, competent for transcription, but cell-specific factors are involved in the induced expression of these genes.

PubMed ID: 8619958
Article link: Int J Dev Biol


Species referenced: Xenopus laevis
Genes referenced: actc1 h1-0 h4c1 h4c4 myod1
Antibodies: H1f0 Ab1 acetylated hist1h4a Ab7 penta-acetylated hist1h4a Ab6


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