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Development 2005 Apr 01;1327:1737-48. doi: 10.1242/dev.01726.
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Dorsoventral patterning of the Xenopus eye: a collaboration of Retinoid, Hedgehog and FGF receptor signaling.

Lupo G , Liu Y , Qiu R , Chandraratna RA , Barsacchi G , He RQ , Harris WA .

In the developing spinal cord and telencephalon, ventral patterning involves the interplay of Hedgehog (Hh), Retinoic Acid (RA) and Fibroblast Growth Factor (FGF) signaling. In the eye, ventral specification involves Hh signaling, but the roles of RA and FGF signaling are less clear. By overexpression assays in Xenopus embryos, we found that both RA and FGF receptor (FGFR) signaling ventralize the eye, by expanding optic stalk and ventral retina, and repressing dorsal retina character. Co-overexpression experiments show that RA and FGFR can collaborate with Hh signaling and reinforce its ventralizing activity. In loss-of-function experiments, a strong eye dorsalization was observed after triple inhibition of Hh, RA and FGFR signaling, while weaker effects were obtained by inhibiting only one or two of these pathways. These results suggest that the ventral regionalization of the eye is specified by interactions of Hh, RA and FGFR signaling. We argue that similar mechanisms might control ventral neural patterning throughout the central nervous system.

PubMed ID: 15753216
Article link: Development

Species referenced: Xenopus
Genes referenced: aldh1a2 aldh1a3 atr fgf8 gal.2 ihh pax2 pax6 rax shh tbx2 tbx5 vax1 vax2 ventx2.2

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