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XB-ART-26925
Brain Res 1989 Feb 06;4791:162-6. doi: 10.1016/0006-8993(89)91347-4.
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Steady-state levels of pro-dynorphin-related end-products from the brain of the amphibian, Xenopus laevis.

Sei CA , Richard R , Dores RM .


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Steady-state analyses of prodynorphin-derived opioid peptides were conducted on acid extracts of the brain of the frog. Xenopus laevis. Radioimmunoassays specific for dynorphin A(1-17), dynorphin A(1-8), alpha-neoendorphin and dynorphin B coupled with gel filtration chromatography and reverse phase high performance liquid chromatography were used. The major prodynorphin-related end-product detected was alpha-neoendorphin. Interestingly, Leu-enkephalin was also detected. Since the Xenopus proenkephalin precursor does not contain the Leu-enkephalin sequence, these data suggest that some of the prodynorphin-related end-products had been cleaved to yield Leu-enkephalin.

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Species referenced: Xenopus laevis
Genes referenced: pdyn penk