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Gene Expr Patterns 2004 Nov 01;51:51-60. doi: 10.1016/j.modgep.2004.06.007.
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Cloning and characterisation of the immunophilin X-CypA in Xenopus laevis.

Massé K , Bhamra S , Haldin CE , Jones EA .

This paper reports the cloning of Xenopus laevis, cyclophilin A gene, X-CypA. This study is the first developmental and functional characterisation in vivo of cyclophilin A in a vertebrate. X-CypA belongs to the superfamily of the immunophilin/PPIase proteins that can bind the immunosuppressant drug Cyclosporin A. Sequence analysis showed that X-CypA is highly conserved during evolution. RT-PCR and in situ hybridisation analysis showed that X-CypA expression is regulated during development and its transcripts are found in three major expression domains: nervous system, sensory organs and pronephros. Over-expression of X-CypA in embryos, analysed by in situ hybridisation and RT-PCR, leads to an expansion and disorganisation of the neural crest domain.

PubMed ID: 15533818
Article link: Gene Expr Patterns
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: egr2 en2 fkbp4 hoxb9 hoxc9-like ppia snai2

Article Images: [+] show captions