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Proc Natl Acad Sci U S A 1985 Oct 01;8220:7111-5.
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Differentiating effects of murine nerve growth factor in the peripheral and central nervous systems of Xenopus laevis tadpoles.

Levi-Montalcini R , Aloe L .

The present investigation was directed toward exploration of the spectrum of action of murine nerve growth factor (m-NGF) in peripheral cells and neurons in the central nervous system (CNS) of Xenopus laevis tadpoles. It was found that systemic m-NGF injections elicit growth and differentiative effects not only on sensory and sympathetic nerve cells but also on several populations in the CNS. The finding that aminergic and peptidergic neurons in brain centers are highly receptive to m-NGF activity provides evidence for the broad spectrum of action of this molecule in lower vertebrates and calls for a systematic search for these and other putative target cells in the CNS of higher vertebrates.

PubMed ID: 3863142
PMC ID: PMC391320
Article link: Proc Natl Acad Sci U S A

Species referenced: Xenopus laevis
Genes referenced: ngf penk sst.1 tac1
Antibodies: Tac1 Ab1

Article Images: [+] show captions
References [+] :
Aloe, Light and electron microscopic studies on the excessive growth of sympathetic ganglia in rats injected daily from birth with 6-OHDA and NGF. 1975, Pubmed