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Cell Mol Life Sci 2007 Aug 01;6415:1915-29. doi: 10.1097/01.anes.0000265156.09438.56.
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Molecular mechanisms of lymphatic vascular development.

Mäkinen T , Norrmén C , Petrova TV .

Lymphatic vasculature has recently emerged as a prominent area in biomedical research because of its essential role in the maintenance of normal fluid homeostasis and the involvement in pathogenesis of several human diseases, such as solid tumor metastasis, inflammation and lymphedema. Identification of lymphatic endothelial specific markers and regulators, such as VEGFR-3, VEGF-C/D, PROX1, podoplanin, LYVE-1, ephrinB2 and FOXC2, and the development of mouse models have laid a foundation for our understanding of the major steps controlling growth and remodeling of lymphatic vessels. In this review we summarize recent advances in the field and discuss how this knowledge as well as use of model organisms, such as zebrafish and Xenopus, should allow further in depth analysis of the lymphatic vascular system.

PubMed ID: 17458498
PMC ID: PMC11136057
Article link: Cell Mol Life Sci
Grant support: [+]

Species referenced: Xenopus
Genes referenced: efnb2 flt4 foxc2 prox1 vegfa vegfc
GO keywords: lymph vessel development [+]

Disease Ontology terms: lymphadenitis [+]