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Biochem Biophys Res Commun 2007 Sep 14;3611:74-8. doi: 10.1016/j.bbrc.2007.06.158.
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Identification and preliminary function study of Xenopus laevis DRR1 gene.

Zhao XY , Liang SF , Yao SH , Ma FX , Hu ZG , Yan F , Yuan Z , Ruan XZ , Yang HS , Zhou Q , Wei YQ .

Xenopus laevis has recently been determined as a novel study platform of gene function. In this study, we cloned Xenopus DRR1 (xDRR1), which is homologous to human down-regulated in renal carcinoma (DRR1) gene. Bioinformatics analysis for DRR1 indicated that xDRR1 shared 74% identity with human DRR1 and 66% with mouse DRR1, and the phlogenetic tree of DRR1 protein was summarized. The xDRR1 gene locates in nuclei determined by transfecting A549 cells with the recombinant plasmid pEGFP-N1/xDRR1. RT-PCR analysis revealed that xDRR1 gene was expressed in all stages of early embryo development and all kinds of detected tissues, and whole-mount in situ hybridization showed xDRR1 was mainly present along ectoderm and mesoderm. Furthermore, xDRR1 expression could suppress A549 cell growth by transfecting with plasmid pcDNA3.1(+)/xDRR1. xDRR1 probably plays important roles involving in cell growth regulation and Xenopus embryo development.

PubMed ID: 17637457
Article link: Biochem Biophys Res Commun

Species referenced: Xenopus laevis
Genes referenced: fam107a odc1

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