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Cell 2008 Feb 08;1323:434-48. doi: 10.1016/j.cell.2007.12.038.
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A combinatorial code for CPE-mediated translational control.

Piqué M , López JM , Foissac S , Guigó R , Méndez R .

Cytoplasmic polyadenylation plays a key role in the translational control of mRNAs driving biological processes such as gametogenesis, cell-cycle progression, and synaptic plasticity. What determines the distinct time of polyadenylation and extent of translational control of a given mRNA, however, is poorly understood. The polyadenylation-regulated translation is controlled by the cytoplasmic polyadenylation element (CPE) and its binding protein, CPEB, which can assemble both translational repression or activation complexes. Using a combination of mutagenesis and experimental validation of genome-wide computational predictions, we show that the number and relative position of two elements, the CPE and the Pumilio-binding element, with respect to the polyadenylation signal define a combinatorial code that determines whether an mRNA will be translationally repressed by CPEB, as well as the extent and time of cytoplasmic polyadenylation-dependent translational activation.

PubMed ID: 18267074
Article link: Cell

Species referenced: Xenopus laevis
Genes referenced: cpeb1 pum1

References :
Richter, Breaking the code of polyadenylation-induced translation. 2008, Pubmed, Xenbase