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Dev Dyn 2009 Apr 01;2384:835-52. doi: 10.1002/dvdy.21901.
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Overlapping functions of Cdx1, Cdx2, and Cdx4 in the development of the amphibian Xenopus tropicalis.

Faas L , Isaacs HV .

Using Xenopus tropicalis, we present the first analysis of the developmental effects that result from knocking down the function of the three Cdx genes present in the typical vertebrate genome. Knockdowns of individual Cdx genes lead to a similar range of posterior defects; compound Cdx knockdowns result in increasingly severe posterior truncations, accompanied by posterior shifts and reduction of 5' Hox gene expression. We provide evidence that Cdx and Wnt3A genes are components of a positive feedback loop operating in the posterior axis. We show that Cdx function is required during later, but not early stages of development, for correct regional specification of the endoderm and morphogenesis of the gut. Our results support the hypothesis that during amphibian development the overall landscape of Cdx activity in the embryo is more important than the specific function of individual Cdx proteins.

PubMed ID: 19301404
PMC ID: PMC2701559
Article link: Dev Dyn
Grant support: [+]

Species referenced: Xenopus tropicalis Xenopus laevis
Genes referenced: cad cdx1 cdx2 cdx4 darmin evx1 fabp2 fgf4 hoxa9 hoxb9 myc myod1 slc5a8 sox2 tal1 tbxt ventx2.2 wnt11 wnt3a wnt5a
Morpholinos: cdx1 MO2 cdx1 MO3 cdx2 MO1 cdx2 MO2 cdx4 MO1

Article Images: [+] show captions
References [+] :
Beck, The role of Cdx genes in the mammalian gut. 2004, Pubmed