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Dev Dyn 2009 Jun 01;2386:1309-20. doi: 10.1002/dvdy.21979.
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In vitro organogenesis from undifferentiated cells in Xenopus.

Asashima M , Ito Y , Chan T , Michiue T , Nakanishi M , Suzuki K , Hitachi K , Okabayashi K , Kondow A , Ariizumi T .

Amphibians have been used for over a century as experimental animals. In the field of developmental biology in particular, much knowledge has been accumulated from studies on amphibians, mainly because they are easy to observe and handle. Xenopus laevis is one of the most intensely investigated amphibians in developmental biology at the molecular level. Thus, Xenopus is highly suitable for studies on the mechanisms of organ differentiation from not only a single fertilized egg, as in normal development, but also from undifferentiated cells, as in the case of in vitro organogenesis. Based on the established in vitro organogenesis methods, we have identified many genes that are indispensable for normal development in various organs. These experimental systems are useful for investigations of embryonic development and for advancing regenerative medicine. Developmental Dynamics 238:1309-1320, 2009. (c) 2009 Wiley-Liss, Inc.

PubMed ID: 19441056
Article link: Dev Dyn

Species referenced: Xenopus laevis
Genes referenced: actl6a apln aplnr axin1 cfd ctdnep1 cxxc4 dll1 dmrta1 egr2 en2 fezf1 fli1 foxb1 foxg1 fzd8 gata4 gata5 gata6 hapln3 has2 hoxd1 igfbp4 isl1 jag1 kdr lhx1 lhx2 myh6 myl7 myocd ncam1 ndrg1 neurod1 neurog1 nkx2-3 nkx2-5 nkx2-6 nog2 notch1 nppa otx2 pax2 pax6 pax8 pcdh1 rasgrp2 rax rbpms2 rgn sall3 six3 sox2 ssr3 tbx2 tbx20 tbx5 tek tnni3 tubb2b vax1 vcan wnt4 wt1 zfp36l2

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