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XB-ART-40108
J Biol Chem 2009 Sep 18;28438:25560-8. doi: 10.1074/jbc.M109.007690.
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The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways.

Sobeck A , Stone S , Landais I , de Graaf B , Hoatlin ME .


Abstract
Genomic stability requires a functional Fanconi anemia (FA) pathway composed of an upstream "core complex" (FA proteins A/B/C/E/F/G/L/M) that mediates monoubiquitination of the downstream targets FANCD2 and FANCI. Unique among FA core complex members, FANCM has processing activities toward replication-associated DNA structures, suggesting a vital role for FANCM during replication. Using Xenopus egg extracts, we analyzed the functions of FANCM in replication and the DNA damage response. xFANCM binds chromatin in a replication-dependent manner and is phosphorylated in response to DNA damage structures. Chromatin binding and DNA damage-induced phosphorylation of xFANCM are mediated in part by the downstream FA pathway protein FANCD2. Moreover, phosphorylation and chromatin recruitment of FANCM is regulated by two mayor players in the DNA damage response: the cell cycle checkpoint kinases ATR and ATM. Our results indicate that functions of FANCM are controlled by FA- and non-FA pathways in the DNA damage response.

PubMed ID: 19633289
PMC ID: PMC2757957
Article link: J Biol Chem
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: antxr1 atm atr fancd2 fanci fancm

References [+] :
Andreassen, ATR couples FANCD2 monoubiquitination to the DNA-damage response. 2004, Pubmed