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Dev Dyn 2009 Sep 01;2389:2382-7. doi: 10.1002/dvdy.22050.
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Xmc mediates Xctr1-independent morphogenesis in Xenopus laevis.

Haremaki T , Weinstein DC .

In the frog, Xenopus laevis, fibroblast growth factor (FGF) signaling is required for both mesoderm formation and the morphogenetic movements that drive the elongation of the notochord, a dorsal mesodermal derivative; the coordination of these distinct roles is mediated by the Xenopus Ctr1 (Xctr1) protein: maternal Xctr1 is required for mesodermal differentiation, while the subsequent loss of Xctr1 promotes morphogenesis. The signaling cascade activated by FGF in the presence of Ctr1 has been well characterized; however, the Xctr1-independent, FGF-responsive network remains poorly defined. We have identified Xenopus Marginal Coil (Xmc) as a gene whose expression is highly enriched following Xctr1 knockdown. Zygotic initiation of Xmc expression in vivo coincides with a decrease in maternal Xctr1 transcripts; moreover, Xmc loss-of-function inhibits Xctr1 knockdown-mediated elongation of FGF-treated animal cap explants, implicating Xmc as a key effector of Xctr1-independent gastrular morphogenesis.

PubMed ID: 19653324
PMC ID: PMC2782962
Article link: Dev Dyn
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: acta4 actc1 actl6a aldoc arhgap21 atf5 ccnb1 cdca9 cldn6.1 dynll2 fgf2 gal.2 gbx2 hes5.10 hoxb9 khdrbs1 mthfd2 myc npm1 odc1 otx2 pcbd1 pou5f3.3 ppm1d rgma slc31a1 tbx2 ventx2 xmc zp2

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References [+] :
Bassez, Post-transcriptional regulation of ornithine decarboxylase in Xenopus laevis oocytes. 1990, Pubmed, Xenbase