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Development 2009 Oct 01;13619:3289-99. doi: 10.1242/dev.040451.
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A directional Wnt/beta-catenin-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the Xenopus retina.

Agathocleous M , Iordanova I , Willardsen MI , Xue XY , Vetter ML , Harris WA , Moore KB .

Progenitor cells in the central nervous system must leave the cell cycle to become neurons and glia, but the signals that coordinate this transition remain largely unknown. We previously found that Wnt signaling, acting through Sox2, promotes neural competence in the Xenopus retina by activating proneural gene expression. We now report that Wnt and Sox2 inhibit neural differentiation through Notch activation. Independently of Sox2, Wnt stimulates retinal progenitor proliferation and this, when combined with the block on differentiation, maintains retinal progenitor fates. Feedback inhibition by Sox2 on Wnt signaling and by the proneural transcription factors on Sox2 mean that each element of the core pathway activates the next element and inhibits the previous one, providing a directional network that ensures retinal cells make the transition from progenitors to neurons and glia.

PubMed ID: 19736324
PMC ID: PMC2739145
Article link: Development
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: atoh7 casp3.2 cat.2 ccne1 ctnnb1 ebf3 elavl3 lef1 notch1 pcna pou4f4 rbpms rbpms2 rlbp1 rpe sox2 tcf3 vsx1 vxn
Antibodies: Ccna2 Ab1 Pcna Ab2 Rlbp1 Ab1 Sox2 Ab2

Article Images: [+] show captions
References [+] :
Baker, Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development. 1999, Pubmed, Xenbase