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XB-ART-41181
Science 2010 Mar 19;3275972:1518-22. doi: 10.1126/science.1184178.
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CKAMP44: a brain-specific protein attenuating short-term synaptic plasticity in the dentate gyrus.

von Engelhardt J , Mack V , Sprengel R , Kavenstock N , Li KW , Stern-Bach Y , Smit AB , Seeburg PH , Monyer H .


Abstract
CKAMP44, identified here by a proteomic approach, is a brain-specific type I transmembrane protein that associates with AMPA receptors in synaptic spines. CKAMP44 expressed in Xenopus oocytes reduced GluA1- and A2-mediated steady-state currents, but did not affect kainate- or N-methyl-D-aspartate (NMDA) receptor-mediated currents. Mouse hippocampal CA1 pyramidal neurons expressed CKAMP44 at low abundance, and overexpression of CKAMP44 led to stronger and faster AMPA receptor desensitization, slower recovery from desensitization, and a reduction in the paired-pulse ratio of AMPA currents. By contrast, dentate gyrus granule cells exhibited strong CKAMP44 expression, and CKAMP44 knockout increased the paired-pulse ratio of AMPA currents in lateral and medial perforant path-granule cell synapses. CKAMP44 thus modulates short-term plasticity at specific excitatory synapses.

PubMed ID: 20185686
Article link: Science


Species referenced: Xenopus laevis

References [+] :
Farrant, Neuroscience. AMPA receptors--another twist? 2010, Pubmed