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Dev Biol 2004 Jan 01;2651:105-12. doi: 10.1016/j.ydbio.2003.09.030.
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FLASH, a component of the FAS-CAPSASE8 apoptotic pathway, is directly regulated by Hoxb4 in the notochord.

Morgan R , Nalliah A , Morsi El-Kadi AS .

The Hox genes are a family of homeodomain-containing transcription factors that confer positional identity during development. Although their regulation and function have been extensively studied, very little is known of their downstream target genes. Here we show that Hoxb4 directly induces the expression of FLASH in the notochord of embryos after neurulation. FLASH is a component of the FAS-CAPSASE8 apoptotic pathway, and blocking its activity, or that of Hoxb4, prevents apoptosis in the notochord.

PubMed ID: 14697356
Article link: Dev Biol

Species referenced: Xenopus laevis
Genes referenced: casp8ap2 dnajc27 eef1a2 fas hoxb1 hoxb4 hoxb5 hoxb9 hoxd4 mrc1 rap1a
Morpholinos: casp8ap2 MO1 hoxb4 MO1

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